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Genetic Evaluation of AAAS Gene in Early-Onset Achalasia and Alacrima Patients

This study has been completed.
Sponsor:
Information provided by:
Asan Medical Center
ClinicalTrials.gov Identifier:
NCT00856921
First received: March 5, 2009
Last updated: NA
Last verified: March 2009
History: No changes posted

March 5, 2009
March 5, 2009
April 2008
January 2009   (final data collection date for primary outcome measure)
Genetic relationship between achalasia and AAAS gene [ Designated as safety issue: Yes ]
Same as current
No Changes Posted
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Genetic Evaluation of AAAS Gene in Early-Onset Achalasia and Alacrima Patients
To Find Out the Genetic Relationship Between the Early-Onset Achalasia and AAAS Gene

The AAAS gene has been known to cause achalasia, alacrima, adrenal abnormalities and a progressive neurological syndrome. A considerable proportion of achalasia patients have been known to show alacrima (decreased secretion of tears). However, the genetic mechanism between achalasia and alacrima has not been defined yet. The investigators postulated that some proportions of early-onset achalasia could be correlated with AAAS gene; thus, the investigators aimed to investigate the relationship between the AAAS gene and early-onset achalasia.

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Observational
Observational Model: Case-Only
Time Perspective: Retrospective
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Retention:   Samples With DNA
Description:

DNA and genetic analysis

Non-Probability Sample

Early age onset achalasia

  • Achalasia
  • Alacrima
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
19
March 2009
January 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • early age onset
  • primary achalasia patient
  • less than 35 years old

Exclusion Criteria:

  • secondary achalasia patients
Both
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No
Contact information is only displayed when the study is recruiting subjects
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NCT00856921
AAASachalasia
Yes
Kee Wook Jung, Asan Medical Center
Asan Medical Center
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Asan Medical Center
March 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP