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Genetic Susceptibility to Kidney Cancer

This study is currently recruiting participants.
Verified December 2010 by Baylor College of Medicine
Sponsor:
Collaborator:
M.D. Anderson Cancer Center
Information provided by:
Baylor College of Medicine
ClinicalTrials.gov Identifier:
NCT00854022
First received: February 26, 2009
Last updated: December 2, 2010
Last verified: December 2010
History of Changes

February 26, 2009
December 2, 2010
July 2008
July 2013   (final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT00854022 on ClinicalTrials.gov Archive Site
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Genetic Susceptibility to Kidney Cancer
Genetic Susceptibility to Renal Cell Carcinoma

This study will further the understanding of the genetic events leading to the development of RCC; explore the genetic basis for genetic instability and how it affects cancer risk; and eventually provide a means of identifying a subgroup of individuals who are most likely to develop RCC. Such individuals may then be targeted for intervention programs such as chemoprevention or dietary modification.
Not Provided
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

We will utilize the blood collected to run several laboratory analyses that will assess DNA damage/repair, telomere length, telomerase activity, and other genetic instability as predictors of RCC risk. All information linking this unique identifier to the participant will be kept in a secure location under lock-and-key password protected.

In addition, RCC tumor and adjacent normal tissue samples may be obtained from the MDACC Institutional Tissue Bank (ITB) for cases only. The samples obtained will be left over from surgical procedures, so as to prevent any additional distress to the patient.
Probability Sample

Adult patients with newly diagnosed (diagnosed within the year of enrollment) with possible Renal Cell Carcinoma (RCC)
Renal Cell Carcinoma
Not Provided
  • Healthy
    Healthy adults, of any ethnicity, or sex, and with no previous history of cancer, except for non-melanoma skin cancer
  • RCC
    Adult patients with newly diagnosed (diagnosed within the year of enrollment) renal carcinoma (RCC) any ethnicity, or sex, who have not received prior chemotherapy or radiotherapy.
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
1600
July 2014
July 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Adult patients of any ethnicity or sex, who have a been diagnosed with possible Renal Cell Carcinoma within the past year.

Exclusion Criteria:

  • Must not have received chemotherapy, biological therapy or radiation therapy in the 6 months preceding enrollment will
  • Must not have had RCC, or metastatic RCC,
  • Must not have had a renal transplantation
Both
18 Years and older
No
Contact: Carmen Bedford 713-798-2179 bedford@bcm.edu
United States
 
NCT00854022
H-17150
No
Seth P. Lerner, MD, Baylor College of Medicine
Baylor College of Medicine
M.D. Anderson Cancer Center
Principal Investigator: Seth P. Lerner, MD Baylor College of Medicine
Baylor College of Medicine
December 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP