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Mapping Mood in the Subthalamic Nucleus in Parkinson's Disease (PD) (MOOD D)

This study is currently recruiting participants.
Verified November 2011 by Washington University School of Medicine
Sponsor:
Collaborator:
National Institutes of Health (NIH)
Information provided by (Responsible Party):
Washington University School of Medicine
ClinicalTrials.gov Identifier:
NCT00847431
First received: February 17, 2009
Last updated: November 2, 2011
Last verified: November 2011
History of Changes

February 17, 2009
November 2, 2011
December 2008
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Complete list of historical versions of study NCT00847431 on ClinicalTrials.gov Archive Site
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Mapping Mood in the Subthalamic Nucleus in Parkinson's Disease (PD)
Mapping Mood in the Subthalamic Nucleus in PD

The goal of this study is to determine the vulnerability of mood-related neurocircuitry in Parkinson Disease (PD) using deep brain stimulation of the subthalamic nucleus (STN DBS).
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Observational
Observational Model: Case Control
Time Perspective: Prospective
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Non-Probability Sample

PD patients with and without STN DBS
  • Parkinson's Disease
  • Depression
  • Anxiety
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  • STN DBS Group
    PD patients with deep brain stimulators in the subthalamic nucleus. Subjects within this group will be placed into either a 1 contact group, or 2 contact group, depending on contact location requirements for this study.
  • Control Group
    PD patients without deep brain stimulator surgery, with similar symptoms to the study group.
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
103
December 2013
Not Provided

Inclusion Criteria for STN-DBS subjects:

  • Age 40 or older
  • DBS STN Surgery in past 2 to 36 months
  • Ability to tolerate turning off Stimulators
  • Ability to read and comprehend questions
  • English speaking

Exclusion Criteria for STN-DBS subjects:

  • Other severe complications post surgery: stroke, seizure, major loss of consciousness, other brain trauma/surgery, or head injuries(i.e. near drowning), encephalitis, or hydrocephalus, blindness, deafness
  • Clinically determined Dementia ( Most recent MMSE score of >24)

Inclusion Criteria for Control subject:

  • Age 40 or older
  • Ability to read and comprehend questions
  • English speaking

Exclusion Criteria for Control subject:

  • Other severe complications post surgery: stroke, seizure, major loss of consciousness, other brain trauma/surgery, or head injuries(i.e. near drowning), encephalitis, or hydrocephalus, blindness, deafness
  • Clinically determined Dementia ( Most recent MMSE score of >24)
  • Plans to have DBS STN surgery in the next 24 months
Both
40 Years and older
No
Contact: Samantha Blankenship, MSW 314-362-6514 blankenships@npg.wustl.edu
United States
 
NCT00847431
08-0354, RO1 NS058797
No
Washington University School of Medicine
Washington University School of Medicine
National Institutes of Health (NIH)
Principal Investigator: Tamara G Hershey, PhD Washington University School of Medicine
Washington University School of Medicine
November 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP