Bronchoscopy Assisted Sampling of Cells and Fluid From the Lower Respiratory Tract of Human Subjects (SCCOR Bronch)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Raymond Coakley, MD, University of North Carolina, Chapel Hill
ClinicalTrials.gov Identifier:
NCT00840723
First received: February 6, 2009
Last updated: September 3, 2013
Last verified: September 2013

February 6, 2009
September 3, 2013
February 2009
August 2013   (final data collection date for primary outcome measure)
The goal of this project is to define the effect of smoking on key aspects of airway biology. These studies will also provide crucial & novel definition of airway biology in smokers against which COPD & CF patients will be compared. [ Time Frame: At the time of bronchoscopy ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00840723 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
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Not Provided
 
Bronchoscopy Assisted Sampling of Cells and Fluid From the Lower Respiratory Tract of Human Subjects
Bronchoscopy-Assisted Sampling of Cells and Fluid From the Lower Respiratory Tract of Human Subjects

The purpose of this research study is to collect cells and liquid from the air passages of healthy adults, both smokers and non-smokers. These samples will be used for test-tube studies to explore mechanisms of diseases of the respiratory tract, and to compare the samples between people who smoke cigarettes and people who don't. Obtaining these samples requires an invasive procedure called "bronchoscopy".

Not Provided
Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples With DNA
Description:

Whole blood, Bronchial Lavage Fluid (BALF), cytology brushings

Non-Probability Sample

Current cigarette smokers who are otherwise healthy (no lung disease or other chronic illness and healthy controls

Respiratory Diseases
Not Provided
  • Current smokers
    Current cigarette smokers with no other illness
  • Healthy controls
    Healthy non smokers
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
30
August 2013
August 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Current cigarette smokers
  • Must be otherwise healthy with no chronic illness

Exclusion Criteria:

  • Asthma
  • Smoking related lung disease (including bronchitis)
Both
18 Years to 75 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00840723
CTRC 2799, NHLBI P50-HL084934
No
Raymond Coakley, MD, University of North Carolina, Chapel Hill
University of North Carolina, Chapel Hill
Not Provided
Principal Investigator: Raymond Coakley, MD University of North Carolina
University of North Carolina, Chapel Hill
September 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP