Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery

This study is currently recruiting participants. (see Contacts and Locations)
Verified July 2013 by Brigham and Women's Hospital
Sponsor:
Information provided by (Responsible Party):
Simon Body, Brigham and Women's Hospital
ClinicalTrials.gov Identifier:
NCT00833313
First received: January 5, 2009
Last updated: July 29, 2013
Last verified: July 2013

January 5, 2009
July 29, 2013
August 2008
August 2015   (final data collection date for primary outcome measure)
Gene expression [ Time Frame: Immediate ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00833313 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
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Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery
Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery

Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your hair or eyes. Some people may have genes that make it more likely for them to get atrial fibrillation after their heart surgery. This research project is being done to find out if the cells of people who develop atrial fibrillation after heart surgery are different from the cells in people who do not develop atrial fibrillation after surgery.

Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your hair or eyes. Some people may have genes that make it more likely for them to get atrial fibrillation after their heart surgery. This research project is being done to find out if the cells of people who develop atrial fibrillation after heart surgery are different from the cells in people who do not develop atrial fibrillation after surgery.

This study seeks to identify regulatory events in atrial myocyte transcription and translation that are altered by germline variation

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

Atrial tissue sample

Non-Probability Sample

Adult patients undergoing cardiac surgery

Atrial Fibrillation
Other: Atrial biopsy
Biopsy of right atrial free wall
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
240
August 2016
August 2015   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age 20-80 years
  • Undergoing cardiac surgery

Exclusion Criteria:

  • Prior atrial fibrillation or flutter
  • Taking Amiodarone
  • Taking Sotalol
Both
20 Years to 80 Years
No
Contact: Simon C Body, MD 617-732-7330 sbody@partners.org
United States
 
NCT00833313
2008-P000896
No
Simon Body, Brigham and Women's Hospital
Brigham and Women's Hospital
Not Provided
Principal Investigator: Simon C Body, MD Brigham and Women's Hospital
Brigham and Women's Hospital
July 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP