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Evaluation of Apathy Using Attentional Reaction Test in Neurodegenerative Diseases

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Centre Hospitalier Universitaire de Nice
ClinicalTrials.gov Identifier:
NCT00833274
First received: January 28, 2009
Last updated: December 8, 2011
Last verified: December 2011

January 28, 2009
December 8, 2011
February 2009
October 2011   (final data collection date for primary outcome measure)
Reaction times (ms), using a computerized test [ Time Frame: one time point, at day 0 (day of inclusion) during the computerized test ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00833274 on ClinicalTrials.gov Archive Site
Apathy severity, using a specific apathy scale (Apathy Inventory) [ Time Frame: one time point, at day 0 (day of inclusion), during the visit ] [ Designated as safety issue: No ]
Apathy severity, using a specific apathy scle (Apathy Inventory) [ Time Frame: one time point, at day 0 (day of inclusion), during the visit ] [ Designated as safety issue: No ]
Not Provided
Not Provided
 
Evaluation of Apathy Using Attentional Reaction Test in Neurodegenerative Diseases
Evaluation of Apathy Using Attentional Reaction Test in Neurodegenerative Diseases

Apathy, defined as a lack of motivation in behaviour, cognition and affect, is common in neurodegenerative diseases. Specific scales are available for the evaluation of apathy but it lacks objective evaluation methods.

The aim of this study is to evaluate the changes in reaction time task according to the presence or absence of reward stimulation and to assess the relation between these performances and apathy scales.

MATERIAL: 13 patients with Mild Cognitive Impairment (MCI), 15 patients with Alzheimer's disease (AD) and 91 elderly healthy subjects were enrolled. A computerized test using the experiment software E-prime® was designed to assess reaction times (in ms) in different experimental conditions after a training trial (neutral, stimulation, stress, stimulation after stress, extinction) and relation between the performances to the test and the Apathy Inventory (AI) scores (lack of initiative, lack of interest, emotional blunting) were observed.

METHOD: Using a computerized test, each patient is asked to press a button (mouse of the computer) each time the screen of the computer becomes completely white. After pressing the button, a randomized colorized geometric figure appears on the screen, and disappears automatically after a few seconds, replaced by a new white screen. Reaction time (in ms) between a white screen and a press of the button is analysed. After a training trial, reaction times are analysed in different experimental conditions: neutral - stimulation1 (patient gets points when pressing the button) - stress (alarm) - stimulation2 (patient gets points when pressing, after the stress trial) - extinction (similar to neutral condition).

Interventional
Not Provided
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Alzheimer Disease
Behavioral: computerized test
Using a computerized test, each patient is asked to press a button (mouse of the computer) each time the screen of the computer becomes completely white.
Experimental: 1
Using a computerized test, each patient is asked to press a button (mouse of the computer) each time the screen of the computer becomes completely white.
Intervention: Behavioral: computerized test
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
70
October 2011
October 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Elderly patients with diagnosis of Alzheimer's Disease according to DSM-IV criteria
  • MMSE >20

Exclusion Criteria:

  • None
  • Motor or psychiatric disorders
Both
65 Years to 75 Years
Yes
Contact information is only displayed when the study is recruiting subjects
France
 
NCT00833274
06-CIR-01
No
Centre Hospitalier Universitaire de Nice
Centre Hospitalier Universitaire de Nice
Not Provided
Not Provided
Centre Hospitalier Universitaire de Nice
December 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP