REAL3 Trial of Efficacy of EOX With/Without Panitumumab in Previously Untreated Adv OG Cancer

This study has been terminated.
(Lack of efficacy)
Sponsor:
Information provided by (Responsible Party):
Professor David Cunningham, Royal Marsden NHS Foundation Trust
ClinicalTrials.gov Identifier:
NCT00824785
First received: January 16, 2009
Last updated: December 10, 2012
Last verified: December 2012

January 16, 2009
December 10, 2012
May 2008
February 2013   (final data collection date for primary outcome measure)
Overall survival [ Time Frame: Early termination ] [ Designated as safety issue: No ]
Study closed early due to lack of efficacy
Overall survival: defined as the time from randomisation to the time of death due to any cause
Complete list of historical versions of study NCT00824785 on ClinicalTrials.gov Archive Site
response rate, toxicity, quality of life and PFS [ Time Frame: Early termination ] [ Designated as safety issue: No ]
Study closed early due to lack of efficacy
response rate evaluated by RECIST criteria progression free survival: defined as the date of randomisation until a progression event occurs
Not Provided
Not Provided
 
REAL3 Trial of Efficacy of EOX With/Without Panitumumab in Previously Untreated Adv OG Cancer
REAL 3 : A Randomised Open-labelled Multicentre Trial of the Efficacy of Epirubicin, Oxaliplatin and Capecitabine (EOX) With or Without Panitumumab in Previously Untreated Advanced Oesophago-gastric Cancer

To determine whether adding panitumumab, an antibody against the epidermal growth factor receptor (EGFR), to standard chemotherapy with epirubicin, oxaliplatin and capecitabine (EOX), improves the duration of survival of patients with advanced stomach and oesophageal cancer.

Multicentre phase III, open labelled, randomised controlled trial. Randomisation will be 1:1 Arm A EOX and Arm B EOX + panitumumab. There will be a pilot phase II study of which the first 200 patients will be randomised and the primary endpoint for interim analysis will be when these patients have completed 6 months follow-up

Interventional
Phase 3
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Oesophago-gastric Cancer
  • Drug: epirubicin, oxaliplatin, capecitabine (EOX)
    epirubicin 50mg/m(2) IV on day 1 oxaliplatin 130mg/m(2) IV on day 1 with hydration capecitabine 1250mg/m(2)/day PO in two divided doses continuously from days 1-21
  • Drug: EOX + panitumumab
    epirubicin 50mg/m(2) IV on day 1 oxaliplatin 100mg/m(2) IV on day 1 with hydration capecitabine 1000mg/m(2)/day PO in two divided doses continuously from days 1-21 panitumumab -9 mg/kg every 21 days
  • Active Comparator: Arm A EOX
    EOX chemotherapy (epirubicin, oxaliplatin and capecitabine)
    Intervention: Drug: epirubicin, oxaliplatin, capecitabine (EOX)
  • Active Comparator: Arm B EOX + panitumumab.
    EOX chemotherapy with the addition of panitumumab 9mg/kg every 21 days
    Intervention: Drug: EOX + panitumumab
Waddell T, Chau I, Cunningham D, Gonzalez D, Frances A, Okines C, Wotherspoon A, Saffery C, Middleton G, Wadsley J, Ferry D, Mansoor W, Crosby T, Coxon F, Smith D, Waters J, Iveson T, Falk S, Slater S, Peckitt C, Barbachano Y. Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial. Lancet Oncol. 2013 May;14(6):481-9. doi: 10.1016/S1470-2045(13)70096-2. Epub 2013 Apr 15.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Terminated
574
February 2013
February 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Histologically verified inoperable locally advanced or metastatic adenocarcinoma or undifferentiated carcinoma of the oesophagus, oesophago-gastric junction, or stomach.
  • Slides of tumour tissue should be available for centralised EGFR staining
  • Uni-dimensionally measurable disease (CT or MRI as per RECIST).
  • No prior chemotherapy including previous adjuvant chemotherapy
  • No prior radiotherapy including adjuvant radiotherapy. Patients receiving palliative radiotherapy to sites of disease that are not measurable may be eligible and should be discussed with the Chief Investigator.
  • Male/female patients aged ≥18 years.
  • WHO Performance status 0, 1 or 2.
  • Patients should have a projected life expectancy of at least 3 months.
  • Completion of baseline quality of life questionnaire (EORTC QLQ C30).
  • Adequate cardiac function; formal measurement of left ventricular ejection fraction is only required if clinically indicated.
  • Adequate bone marrow function: absolute neutrophil count (ANC) ≥1.5x109/l; white blood cell count ≥ 3x109/l; platelets ≥ 100x109/l; haemoglobin (Hb) ≥ 9g/dl (can be post-transfusion).
  • Adequate renal function: calculated creatinine clearance ≥50ml/minute.
  • Adequate liver function: serum bilirubin ≤1.5x ULN; ALT/AST ≤2.5x ULN; ALP ≤3x ULN (in the absence of liver metastases). If liver metastases are present, serum transaminases ≤5x ULN are permitted.
  • Written informed consent must be obtained from the patient before any study-specific procedures are performed (see Section 12.0).

Note: Epidermal growth factor receptor (EGFR) positivity by immunohistochemistry will not be required for study entry. Slides obtained from previously collected paraffin embedded archived specimens will be collected centrally for EGFR staining. A multivariate analysis will then be performed to exclude any effects of EGFR status on outcome measures

Exclusion Criteria:

  • Tumours of squamous histology.
  • Patients with locally advanced oesophageal cancer suitable for definitive chemoradiotherapy.
  • Documented or symptomatic brain metastases and/or central nervous system metastases or leptomeningeal disease.
  • Previous chemotherapy or radiotherapy. See Inclusion criteria for note regarding palliative radiotherapy.
  • Any major surgery within 4 weeks prior to the start of study treatment.
  • Any prior treatment with an EGFR signal transduction directed therapy.
  • Treatment with non-permitted medication.
  • Clinically significant (i.e. active) cardiac disease e.g. symptomatic coronary artery disease, uncontrolled cardiac dysrhythmia, or myocardial infarction within the last 12 months. Patients with any history of clinically significant cardiac failure are excluded from study entry.
  • History of interstitial lung disease (e.g., pneumonitis or pulmonary fibrosis) or evidence of interstitial lung disease on baseline chest CT scan.
  • Known peripheral neuropathy >Grade 1 (absence of deep tendon reflexes as the sole neurological abnormality does not render the patient ineligible).
  • Lack of physical integrity of the upper gastro-intestinal tract, malabsorption syndrome, or inability to take oral medication (administration of capecitabine by naso-gastric or jejunostomy feeding tube is permitted).
  • Known dihydropyrimidine dehydrogenase (DPD) deficiency.
  • Known hypersensitivity to panitumumab, components of the EOX regimen, or any of the constituents of these agents.
  • Known positive tests for human immunodeficiency virus (HIV) infection, hepatitis C virus, acute or chronic active hepatitis B infection.
  • Other clinically significant disease or co-morbidity which may adversely affect the safe delivery of treatment within this trial.
  • Female patients who may be pregnant or breastfeeding. Potential female patients of childbearing potential must have a negative pregnancy test within 7 days prior to randomisation, or have had amenorrhea for more than 2 years.
  • Patients of child-bearing potential not consenting to use adequate contraceptive precautions or abstinence during the course of the study and for 6 months after the last study drug administration for females, and 1 month for males.
  • Any other malignancies within the last 5 years (other than curatively treated basal cell carcinoma of the skin and/or in situ carcinoma of the cervix).
  • Treatment with another investigational agent within 30 days of commencing study treatment.
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT00824785
CCR3024
Yes
Professor David Cunningham, Royal Marsden NHS Foundation Trust
Royal Marsden NHS Foundation Trust
Not Provided
Principal Investigator: Prof Cunningham, David Royal Marsden NHS Foundation Trust
Royal Marsden NHS Foundation Trust
December 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP