Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2010 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00808691
First received: December 15, 2008
Last updated: June 28, 2010
Last verified: June 2010

December 15, 2008
June 28, 2010
September 2007
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Mortality Severity of Organ Failure [ Time Frame: 28 days ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00808691 on ClinicalTrials.gov Archive Site
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Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
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As medicine advances, many lives can be saved in the intensive care unit. However, when multiple organ failure occurs, the mortality rate of patients increases dramatically. Therefore, the major goal in the intensive care unit is to prevent the occurrence of multiple organ failure. The sepsis protocol and early goal directed treatment have great effects to reduce development of multiple organ failure and to decrease the mortality rate. However, sometime the condition of patient deteriorated in spite of both the mean blood pressure and mixed venous oxygen saturation are normal. Some experts recognize that there might be microcirculatory dysfunction of tissue or organ. The dysfunction of microcirculation might due to vasoconstriction or microthrombosis. Vasoconstriction might result from systemic inflammation, reactive oxygen species, or dysfunction of synthesis of NO (nitric oxide). Microthrombosis might result from systemic inflammation, reactive oxygen species, imbalance of coagulatory system, or damage of endothelial cell.

In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. This study tries to investigate the relation between oxidative stress and microcirculation. Furthermore, the investigators will try to investigate the correlation between the severity of oxidative stress and microcirculatory dysfunction and the severity of disease and prognosis. The investigators hope this study will help them to figure out the picture of disease progression of patients. It may conduct further study to modulate the oxidative stress, to improve the microcirculatory function, and finally to improve the outcome of patients.

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Observational
Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample

Paitents admitted to intensive care unit with the following conditions Sepsis Postoperative care ARDS Renal Failure Liver failure Brain death

  • Sepsis
  • Postoperative Care
  • ARDS
  • Liver Failure
  • Renal Failure
  • Brain Death
Other: Critical care
Standard care for each group of patients
  • 1
    Patients with sepsis
    Intervention: Other: Critical care
  • 2
    Patient admitted for postoperative care
    Intervention: Other: Critical care
  • 3
    Patients with ARDS
    Intervention: Other: Critical care
  • 4
    Patients with ARF
    Intervention: Other: Critical care
  • 5
    Patients who receive liver support treatment
    Intervention: Other: Critical care
  • 6
    Patients wiht brain death
    Intervention: Other: Critical care
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
280
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Inclusion Criteria:

  • > 18 y/o
  • Related diagnosis made within 24h
  • Group 1 - Sepsis
  • Group 2 - Postoperative care
  • Group 3 - ARDS
  • Group 4 - Renal failure
  • Group 5 - Liver failure
  • Group 6 - Brain death

Exclusion Criteria:

  • Pregnant patients
  • Related diagnosis made longer than 24h
  • Patients who have received antioxidants within 24h
  • Patients who have received hyperbaric oxygen therapy
  • Patients who have a hemoglobin value less than 9 g/dl
  • Patients who have received NO
Both
18 Years and older
No
Contact: Yu-Chang Yeh, MD 886-9-68661829 tonyyeh@ntuh.gov.tw
Taiwan
 
NCT00808691
200707012
No
Yu-Chang Yeh/Doctor, National Taiwan University Hospital
National Taiwan University Hospital
Not Provided
Principal Investigator: Yu-Chang Yeh, M.D National Taiwan University Hospital
National Taiwan University Hospital
June 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP