Increased Expression of Adiponectin Receptor 2 in the Mononuclear Cells in Children With Prader-Willi Syndrome

This study has been completed.
Sponsor:
Information provided by:
Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT00800852
First received: November 30, 2008
Last updated: December 1, 2008
Last verified: November 2008

November 30, 2008
December 1, 2008
Not Provided
Not Provided
Not Provided
Not Provided
Complete list of historical versions of study NCT00800852 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Increased Expression of Adiponectin Receptor 2 in the Mononuclear Cells in Children With Prader-Willi Syndrome
Increased Expression of Adiponectin Receptor 2 in the Mononuclear Cells in Children With Prader-Willi Syndrome

The inflammatory process is involved in the pathogenesis of obesity. Prader-Willi syndrome (PWS) is a genetic model of syndromic obesity. Adiponectin is an adipokine with potent anti-inflammatory properties, and its effect is mediated through adiponectin receptors 1 (adipoR1) and 2 (adipoR2).

Objective of this study is to compare the expression of adipoR1, adipoR2, and adiponectin in peripheral blood mononuclear cells (PBMCs) in PWS children and obese control and to correlate receptor expression with insulin sensitivity and obesity-related parameters.

Not Provided
Observational
Not Provided
Not Provided
Not Provided
Probability Sample

Fourteen children with PWS and control subjects

  • Obesity
  • Prader-Willi Syndrome
Not Provided
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
Not Provided
Not Provided
Not Provided

Inclusion Criteria:

  • children with Prader-willi syndrome
  • children with simple obesity

Exclusion Criteria:

  • subjects with diabetes mellitus (fasting plasma glucose > 126 mg/dL with a 2-h oral glucose tolerance test value of >200 mg/dl)
Both
up to 18 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
NCT00800852
2008-10-040
Yes
Dong-Kyu Jin, Samsung Medical Center
Samsung Medical Center
Not Provided
Principal Investigator: Don-Kyu Jin, M.D. Samsung Medical Center, Sungkyunkwan Uiversity School of Medicine
Samsung Medical Center
November 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP