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Immunologic Abnormalities, Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease (CKD)

This study has been completed.
Sponsor:
Collaborators:
Beckman Laser Institute University of California Irvine
Volighten Scientific, Ltd.
Information provided by (Responsible Party):
Montana Compton, University of California, Irvine
ClinicalTrials.gov Identifier:
NCT00793806
First received: November 14, 2008
Last updated: December 26, 2012
Last verified: December 2012
History of Changes

November 14, 2008
December 26, 2012
August 2008
March 2012   (final data collection date for primary outcome measure)
clinical parameters cause of chronic kidney disease [ Time Frame: 4 weeks ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00793806 on ClinicalTrials.gov Archive Site
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Immunologic Abnormalities, Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease (CKD)
Non-invasive Spectroscopic Measurements of the Concentrations of Blood, Water, and Lipids in Tissues

The Diffuse Optical Spectroscopy (DOS) measure the absolute concentrations of reduced and oxygenated hemoglobins ([Hb-R] and [HbO2], respectively) as well as the water and lipid concentrations of the tissue.

DOS have been shown to correlate with invasive measures of cardiac output, mean arterial pressure, blood loss, and blood hemoglobin concentration.

The researchers want to use DOS as a means to monitor volume changes during the hemodialysis treatment and to correlate the changes in volume and blood pressure with the measures of oxidative stress and inflammation used in this study.

The researchers want compared to a variety of laboratory parameters routinely measured in CKD subjects (GFR, proteinuria, Hg, serum albumin, bicarbonate, calcium, phosphorous, iron saturation, ferritin, lipid profiles, PTH) and to clinical parameters such as cause of CKD, blood pressure and dialysis-related parameters.
Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Non-Probability Sample

primary care clinic
Chronic Kidney Disease
Device: Diffuse Optical Spectroscopy
near-infrared (NIR)
Other Name: DOS
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
14
March 2012
March 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • 18 years and older with chronic kidney disease undergoing hemodialysis have been treated with hemodialysis for at least 3 months
  • 18 years and older for control

Exclusion Criteria:

  • acute kidney disease
Both
18 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00793806
LAMMP DOS
No
Montana Compton, University of California, Irvine
Montana Compton
  • Beckman Laser Institute University of California Irvine
  • Volighten Scientific, Ltd.
Principal Investigator: Madeleine Pahl, M.D. University of California, Irvine
University of California, Irvine
December 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP