Myocilin Variations and Familial Glaucoma in Taxiarchis

This study is currently recruiting participants.
Verified January 2013 by Aristotle University Of Thessaloniki
Sponsor:
Information provided by (Responsible Party):
AGP Konstas, Aristotle University Of Thessaloniki
ClinicalTrials.gov Identifier:
NCT00788762
First received: November 7, 2008
Last updated: January 25, 2013
Last verified: January 2013

November 7, 2008
January 25, 2013
August 2007
June 2015   (final data collection date for primary outcome measure)
Examining all of the villagers to determine the actual incidence of glaucoma in Taxiarchis and identify the Thr377Met myocilin mutation in glaucoma patients. [ Time Frame: 4 years ] [ Designated as safety issue: No ]
Examining all of the villagers to determine the actual incidence of glaucoma in Taxiarchis and identify the Thr377Met myocilin mutation in glaucoma patients. [ Time Frame: 3 years ] [ Designated as safety issue: No ]
Complete list of historical versions of study NCT00788762 on ClinicalTrials.gov Archive Site
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Myocilin Variations and Familial Glaucoma in Taxiarchis
Myocilin Variations and Familial Glaucoma in Taxiarchis, A Small Greek Village.

Taxiarchis, a small village in Northern Greece with 1060 inhabitants, was considered to have a surprisingly high incidence of glaucoma. This isolated population located on Mount Holomondas appeared to be enriched for familial glaucoma. Based upon the high reported incidence of glaucoma in Taxiarchis and previous findings of the Thr377Met myocilin mutation in the Greek population,the investigators undertook a community-based study to determine if this variant was present in this village.

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Observational
Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:

Myocilin screening was performed from blood or saliva specimens taken from the village. The promoter region and exons 1-3 of myocilin were sequenced at the Portland Veterans Administration Medical center. Microsatellite marker analysis in the GLC1A region, including D1S452, D1S1619, D1S2790 and D1S242 was performed at deCODE (Reykjavik, Iceland).

Non-Probability Sample

Villagers from Taxiarchis

Glaucoma
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Villagers in Taxiarchis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
800
December 2015
June 2015   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Individuals born in Taxiarchis

Exclusion Criteria:

  • Individuals that have not been born in Taxiarchis
Both
1 Year to 90 Years
No
Contact: Anastasios G Konstas, MD, PhD 2310-994774 konstas@med.auth.gr
Contact: Georgios Moumtzis, MD 2310-994742
Greece
 
NCT00788762
A6798
No
AGP Konstas, Aristotle University Of Thessaloniki
Aristotle University Of Thessaloniki
Not Provided
Principal Investigator: Anastasios G Konstas, MD, PhD Glaucoma Unit, 1st University Dept
Aristotle University Of Thessaloniki
January 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP