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Analysis of Immunological Reactions to Foods in Birch Pollen-Allergic Patients

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2008 by Medical University of Vienna.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Medical University of Vienna
ClinicalTrials.gov Identifier:
NCT00787631
First received: October 23, 2008
Last updated: November 6, 2008
Last verified: October 2008

October 23, 2008
November 6, 2008
December 2008
January 2010   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00787631 on ClinicalTrials.gov Archive Site
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Analysis of Immunological Reactions to Foods in Birch Pollen-Allergic Patients
Analysis of Immunological Reactions to Pollen-Related Foods in Birch Pollen-Allergic Patients

A high number of birch pollen-allergic individuals develop hypersensitivity reactions to certain foods, e.g. apples. This food allergy is due to immunological cross-reactivity. Birch pollen-related foods contain proteins, e.g. Mal d 1 in apple, that are structurally related with the major birch pollen allergen, Bet v 1. Hence IgE antibodies and T lymphocytes specific for Bet v 1 recognize these food proteins which results in activation of the immune system and, consequently, in clinical symptoms.

In the present study the investigators intend to investigate if and how the consumption of birch pollen-related food allergens affects birch pollen allergy. In other words, the investigators are interested to analyse whether Bet v 1-related food allergens activate Bet v 1-specific memory cells and thus, contribute to the maintenance of the pollen allergy outside the pollen season. Data obtained in this study will help to clarify the immunological and clinical role of cross-reactivity between pollen and food allergies and will reveal whether avoidance of such foods should be recommended for the patients. Finally, novel approaches for diagnosis and therapy of pollen-related food allergens can be developed.

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Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Non-Probability Sample

otherwise healthy birch pollen allergic (rhinoconjunctivitis)persons suffering also from oral allergy syndrome to apple.

  • Allergic Rhinitis
  • Food Allergy
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
30
December 2010
January 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Otherwise healthy birch pollen allergic (rhinoconjunctivitis)persons
  • Positive SPT and RAST to birch pollen
  • Sensitized to Bet v 1

Exclusion Criteria:

  • Persons suffering from malignancies, autoimmune and cardiopulmonary diseases
  • Anemia
  • Hyper-IgE syndrome
  • Treatment with ß-blockers, permanent treatment with antihistaminics, leucotriene antagonists, corticosteroids
Both
18 Years to 50 Years
No
Contact: Tamar Kinaciyan, Ass.Prof.MD +43140400 ext 7700 tamar.kinaciyan@meduniwien.ac.at
Contact: Barbara Bohle, AssocProf Dr +43140400 ext 5114 barbara.bohle@meduniwien.ac.at
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NCT00787631
TK01/2008
No
Tamar Kinaciyan, MD, Ass. Prof., DIAID, Dep. of Dermatology, MUV
Medical University of Vienna
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Principal Investigator: Tamar Kinaciyan, Ass Prof MD Dept. of Dermatology, Medical University of Vienna
Medical University of Vienna
October 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP