Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2008 by Washington University School of Medicine.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Washington University School of Medicine
ClinicalTrials.gov Identifier:
NCT00785564
First received: November 3, 2008
Last updated: November 4, 2008
Last verified: November 2008

November 3, 2008
November 4, 2008
November 2007
November 2009   (final data collection date for primary outcome measure)
ECGI Image [ Time Frame: 1 month after RV pacing ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00785564 on ClinicalTrials.gov Archive Site
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Imaging Cardiac Electrical Remodeling With Electrocardiogram Imaging (ECGI)
Imaging Cardiac Electrical Remodeling With ECGI

A consequence of chronic RV pacing is a process of electrical remodeling that alters myocardial repolarization to reflect the altered depolarization induced by the RV lead. When RV pacing is discontinued, the altered repolarization persists for several weeks. This phenomena is traditionally described as "T-wave memory" based upon the 12-lead ECG appearance of inverted T-Waves. The investigators are using the ECGI technique to produce three dimensional electroanatomical images of this phenomena in patients with dual chamber pacemakers. Echocardiography will also be used to image the mechanical effects of RV pacing and T-wave memory. The images will show the spatial distribution of altered repolarization and allow us to correlate any mechanical consequences of this phenomena that may exist.

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Observational
Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample

Patients of a pacemaker clinic

Sick Sinus Syndrome
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
10
November 2009
November 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Implanted dual chamber pacemaker for sick sinus syndrome with no history of complete heart block.

Exclusion Criteria:

  • Persistent atrial fibrillation that is not suppressed by medications.
Both
18 Years and older
No
United States
 
NCT00785564
07-0995
No
Mitchell N. Faddis MD, PhD, Washington University School of Medicine
Washington University School of Medicine
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Principal Investigator: Mitchell N Faddis, MD PhD Washington University School of Medicine
Washington University School of Medicine
November 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP