Evaluating the Relationship Between Stress, Ethnicity, and Blood Pressure

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2009 by National Heart, Lung, and Blood Institute (NHLBI).
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00783497
First received: October 30, 2008
Last updated: July 14, 2009
Last verified: July 2009

October 30, 2008
July 14, 2009
October 2005
September 2010   (final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT00783497 on ClinicalTrials.gov Archive Site
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Not Provided
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Evaluating the Relationship Between Stress, Ethnicity, and Blood Pressure
Stress, Blood Pressure, & Ethnicity

High blood pressure is a common health problem among people in the United States. This study will examine the ways that stress and ethnicity play a role in the development of high blood pressure.

High blood pressure affects nearly one third of all people in the United States. It can be caused by many factors, including obesity, sodium intake, genetics, and stress. Ethnicity appears to also play a role, because African Americans are more susceptible to developing high blood pressure than other ethnic groups, with more than 40% of African Americans diagnosed with this condition. This study will examine the underlying reasons of why stress and African-American ethnicity contribute to high blood pressure risk and how ethnicity and stress interact with each other to increase this risk. Specifically, study researchers will examine how stress increases blood pressure, how people from different ethnic groups respond to stress differently, and how sleep plays a role in regulating blood pressure levels.

This study will enroll African Americans and Caucasians who have high blood pressure, as well as African Americans and Caucasians who have normal blood pressure. Potential participants will go through a screening process that involves a medical history review, questionnaires, and blood pressure monitoring. Eligible participants will then be admitted to the research clinic for a 2-night stay. Participants' nutrition history and body measurements will be obtained, and a catheter will be inserted into the arm so that blood can be easily collected during the clinic stay. During the night, participants' breathing habits and movements will be monitored while they sleep. During the day, blood pressure and heart activity will be monitored frequently, including when participants are asked to perform mildly stressful tasks, such as giving a short speech. Various medications that affect heart rate and blood pressure will be given at different times during the study, and researchers will monitor participants' reactions to each medication. Lastly, participants will also complete psychological questionnaires.

Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples With DNA
Description:

Serum, urine

Non-Probability Sample

Community sample in the San Diego, California metropolitan area

Hypertension
Not Provided
  • 1
    Caucasian Americans
  • 2
    African Americans
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
225
December 2010
September 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Self-identifies as African American or Caucasian
  • Weighs 85% to 150% of ideal weight (approximate BMI of 17.5 to 30)
  • In good physical health

Exclusion Criteria:

  • Blood pressure greater than 180/110 mm Hg at any point in the past
  • Currently works less than half-time
  • Currently is employed doing shift work
  • Currently takes prescription medication, other than anti-hypertensive medication
  • Currently smokes
Both
18 Years to 50 Years
Yes
United States
 
NCT00783497
599, 5 R01 HL036005-23
Yes
Joel E. Dimsdale, MD, University of California, San Diego
National Heart, Lung, and Blood Institute (NHLBI)
Not Provided
Principal Investigator: Joel E. Dimsdale, MD University of California, San Diego
National Heart, Lung, and Blood Institute (NHLBI)
July 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP