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Age-Dependent Memory Benefits From Pharmacologically Enhanced Naps?
This study is currently recruiting participants.
Study NCT00773032   Information provided by University of California, San Diego
First Received: October 15, 2008   No Changes Posted

October 15, 2008
October 15, 2008
October 2008
June 2009   (final data collection date for primary outcome measure)
 
 
No Changes Posted
 
 
 
Age-Dependent Memory Benefits From Pharmacologically Enhanced Naps?
 

The purpose of this study is to investigate whether

  1. pharmacologically enhanced naps will show increases in specific sleep stages
  2. whether these sleep stages will produces specific increases on memory tests
  3. whether older adults will benefit more than young adults from increased SWS or Stage 2 on subsequent declarative and motor memory tests.
 
 
Interventional
 
Older Adults
  • Drug: Sodium Oxybate
    2.5g Sodium Oxybate administered during nap
  • Drug: Zolpidem
    5mg Zolpidem administered during nap
  • Drug: placebo
    Placebo administered during nap
  • Sodium Oxybate: Experimental
    2.5g Sodium Oxybate administered during nap
    Intervention: Drug: Sodium Oxybate
  • Zolpidem: Experimental
    5mg Zolpidem administered during nap
    Intervention: Drug: Zolpidem
  • Placebo: Placebo Comparator
    Intervention: Drug: placebo
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Recruiting
 
 
June 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • English-speaking individuals, half men and half women, and between the ages of 60 and 75 years will be recruited. No ethnic group will be specifically excluded from study. All participants will be recruited from general San Diego Community. An education requirement of at least 12 years completed will be imposed, as education may affect performance on the cognitive task.

Exclusion Criteria:

  • Not having a regular sleep-wake schedule (defined as not meeting criteria listed above and/or a Horne-Ostberg Morningness-Eveningness Questionnaire score not between 31-69)
  • Having a sleep disorder (reported or detected on the questionnaires)
  • Any personal or immediate family (i.e., first degree relative) history of diagnosed significant psychopathology
  • Personal history of head injury with loss of consciousness greater than 15 minutes or seizures
  • History of substance dependence
  • Current use of any psychotropic medications
  • Any cardiac, respiratory or other medical condition which may affect cerebral metabolism
  • Given the nature of the stimulus and its presentation, anyone with non-correctable vision and audition impairments will also be excluded.
Both
60 Years to 75 Years
Yes
Contact: Jen Kanady, BA 858-642-3192 jkanady@vapop.ucsd.edu
United States
 
NCT00773032
PI: Sara C. Mednick Ph.D.
071529_OA
University of California, San Diego
 
 
University of California, San Diego
October 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP