Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease

This study is currently recruiting participants. (see Contacts and Locations)
Verified April 2013 by Luzerner Kantonsspital
Sponsor:
Information provided by (Responsible Party):
Prof. Paul Erne, Luzerner Kantonsspital
ClinicalTrials.gov Identifier:
NCT00767013
First received: October 3, 2008
Last updated: April 16, 2013
Last verified: April 2013

October 3, 2008
April 16, 2013
May 2007
December 2013   (final data collection date for primary outcome measure)
Quality of cardiac imaging in computed tomography [ Time Frame: After comparison of imaging measurements ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00767013 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
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Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease
Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease: Dual-source Computed Tomography Compared With Invasive Coronary Angiography and Transthoracic Echocardiography

We sought to determine whether the dual-source computed tomography assessment of aortic valve stenosis and coronary artery disease is equivalent to or even better than conventional invasive coronary angiography and transthoracic echocardiography.

Until now invasive coronary angiography has established itself for the assessment of symptomatic aortic valve stenosis. Literature shows a good correlation between MSCT, MRI, TTE and TEE for evaluating the severity of the aortic valve stenosis.

The dual-source computed tomography (DSCT) is capable of assessing coronary arteries with a high sensitivity and specificity in term of relevant stenosis (>50%), due to its excellent spatial and temporal resolution. This study includes the assessment of patients with symptomatic valve stenosis. The severity of the aortic valve stenosis is being assessed by DSCT and TTE. Significant coronary artery stenosis and its localisation are assessed by DSCT and invasive coronary angiography. We examine the correlation between DSCT on one side and either TTE or invasive coronary angiography on the other.

Interventional
Not Provided
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
  • Aortic Valve Stenosis
  • Coronary Disease
Other: DSCT, TTE
One assessment each
Experimental: AVS, CAD
DSCT
Intervention: Other: DSCT, TTE
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
65
Not Provided
December 2013   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients with aortic valve disease who were scheduled to undergo cardiac surgery

Exclusion Criteria:

  • Hemodynamic instability
  • Renal insufficiency (serum creatinine level > 133umol/L)
  • Known allergy to iodinated contrast agents
  • Non-treated hyperthyreosis
Both
40 Years and older
No
Switzerland
 
NCT00767013
Cardiac imaging DSCT
Yes
Prof. Paul Erne, Luzerner Kantonsspital
Luzerner Kantonsspital
Not Provided
Principal Investigator: Paul Erne, MD Luzerner Kantonsspital
Luzerner Kantonsspital
April 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP