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The Acute Cardiovascular Effects of Marathon Running Using Magnetic Resonance Imaging (MARATHON-MRI)

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Lihua QU, William Beaumont Hospitals
ClinicalTrials.gov Identifier:
NCT00752752
First received: September 12, 2008
Last updated: April 2, 2012
Last verified: April 2012
History of Changes

September 12, 2008
April 2, 2012
September 2008
May 2010   (final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT00752752 on ClinicalTrials.gov Archive Site
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The Acute Cardiovascular Effects of Marathon Running Using Magnetic Resonance Imaging
The Acute Cardiovascular Effects of Marathon Running Using Magnetic Resonance Imaging

Using blood testing and cardiac magnetic resonance imaging (MRI), the investigators aim to determine if there are necrotic areas of myocardium in participants who complete a marathon. In addition, the investigators aim to describe the acute and chronic structural abnormalities that occur as a result of endurance training. The study hypothesis is that myocardial necrosis is present in runners completing a marathon competition.

MARATHON-MI is a prospective, observational study of twenty-five (25) participants with plans of completing the Detroit Free Press Marathon in Detroit, Michigan on October 19, 2008. All participants will undergo a rigorous pre-marathon screening process which will include: 1) blood testing, 2) complete cardiopulmonary exercise testing, 3) ECG testing, 4) Holter monitoring, 5) cardiac MRI. Blood work will be check after the marathon immediately after and one day after the event. Cardiac MRI will be repeated within 12 hours of finishing the marathon. Using the information derived from the blood work and radiological testing, we will attempt to determine if there is an association between marathon running and myocardial necrosis.
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:

Serum
Probability Sample

Twenty-five (25) participants with plans of completing the Detroit Free Press Marathon in Detroit, Michigan on October 19, 2008.
  • Myocardial Ischemia
  • Left Ventricular Systolic Dysfunction
  • Elevated Cardiac Enzymes
Not Provided
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
25
May 2010
May 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Detroit Free Press Marathon participant on October 19, 2008,
  • Age > 18 years old,
  • Ability to provide informed consent.

Exclusion Criteria:

  • Known coronary or structural heart disease
  • Pregnancy,
  • Extreme claustrophobia,
  • Metal implants,
  • Renal dysfunction.
Both
18 Years to 60 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00752752
HIC2008-083
No
Lihua QU, William Beaumont Hospitals
William Beaumont Hospitals
Not Provided
Principal Investigator: Justin E Trivax, MD Physician
William Beaumont Hospitals
April 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP