Biodistribution of Neutrophile Proteases in the Sputum of Patients Affected by Cystic Fibrosis (Pro-Muco)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2008 by University Hospital, Tours.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University Hospital, Tours
ClinicalTrials.gov Identifier:
NCT00750932
First received: September 10, 2008
Last updated: November 13, 2008
Last verified: November 2008

September 10, 2008
November 13, 2008
January 2008
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Complete list of historical versions of study NCT00750932 on ClinicalTrials.gov Archive Site
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Biodistribution of Neutrophile Proteases in the Sputum of Patients Affected by Cystic Fibrosis
Study of the Biodistribution of PMN Serine Proteases in Sputum of Patients Affected by Cystic Fibrosis: Towards New Anti-Inflammatory Therapies

The purpose of the proposed project is to characterize the neutrophile proteases which participate in the chronic inflammatory phenomenon associated with the cystic fibrosis and which are responsible for the degradation of the lung tissue.

The respiratory failure which results from it is one of main causes of the fatal evolution of this pathology but the anti-inflammatory therapies based on the use of antiproteases targeting specifically the soluble elastase did not end, until now, in the hoped results.

The identification of the other noxious targets is a crucial element to give new orientations to the anti-inflammatory strategies based on the administration of antiproteases which remain a promising way.

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Observational
Observational Model: Case Control
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:

Whole blood Sputum

Non-Probability Sample

Adults and children with cystic fibrosis

Cystic Fibrosis
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  • T
    Control
  • M
    Minor with cystic fibrosis
  • A
    Adult with cystic fibrosis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
90
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Inclusion Criteria:

  • Man /woman older than 18 years (for adult and group)
  • Child aged 6 to 18 years (for child group)
  • Suffering from cystic fibrosis in stable condition, ie not having presented thrust acute attack of the broncho-pulmonary or hospitalization for treatment of his illness during the previous 2 weeks

Exclusion Criteria:

  • colonized by Burkholderia cepacia ou Stenotrophomonas maltophilia
  • non smoker (control group)
  • Without history or respiratory respiratory disease known (control group)
  • Antibiotic treatment and / or anti-inflammatory drug (NSAID or corticosteroids) in the 2 weeks prior to the inclusion in the study (control group)
Both
6 Years and older
Yes
Contact: Patrice DIOT, PHD +33247473787 diot@med.univ-tours.fr
Contact: Pascaline RAMEAU +33247474664 rameau@med.univ-tours.fr
France
 
NCT00750932
AOHP07-PD Pro-Muco, DGS2007-0295, N° ID RCB:2007-A00511-52, CPP: 2007-R17
Yes
University Hospital, Tours
University Hospital, Tours
Not Provided
Principal Investigator: Patrice DIOT, PHD Tours Hospital
University Hospital, Tours
November 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP