Cardiovascular Consequences of Intermittent Hypoxia in Healthy Subjects

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2008 by University Hospital, Grenoble.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
University Hospital, Grenoble
ClinicalTrials.gov Identifier:
NCT00746928
First received: September 1, 2008
Last updated: September 3, 2008
Last verified: September 2008

September 1, 2008
September 3, 2008
September 2005
July 2007   (final data collection date for primary outcome measure)
Blood Pressure [ Time Frame: Two Weeks ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00746928 on ClinicalTrials.gov Archive Site
  • Neuronal and humoral sympathetic control and vascular resistance. [ Time Frame: Two weeks ] [ Designated as safety issue: No ]
  • Sleep quality [ Time Frame: Two Weeks ] [ Designated as safety issue: No ]
  • The ventilation under exposure and the long terms effect on ventilation control of CIH (central and peripheral chemoreflex) [ Time Frame: two weeks ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Cardiovascular Consequences of Intermittent Hypoxia in Healthy Subjects
Cardiovascular Consequences of Intermittent Hypoxia in Healthy Subjects

The study is a prospective field evaluation to assess the effects of the chronic Intermittent Hypoxia exposure in 12 healthy humans.

Precisely, the study was designed to :

Set up a new model of Chronic Intermittent Hypoxia (CIH) applied to healthy human. This CIH is mimicking the CIH undergone by patients suffering from Sleep Apnea Syndrome.

Evaluate the cardiovascular effect of CIH. Neuronal and humoral sympathetic control, blood pressure control, vascular resistance.

Evaluate the Sleep quality, the ventilation under exposure and the long terms effect on ventilation control of CIH (central and peripheral chemoreflex).

Investigates the biological aspects of CIH exposure.

Not Provided
Interventional
Not Provided
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Sleep Apnea Syndrome
Other: Chronic Intermittent Hypoxia
Chronic Intermittent Hypoxia mimicking the CIH undergone by patients suffering from Sleep Apnea Syndrome, is applied to Healthy subject during 8 hours a day (nights) for a 14 days period. The cycle of intermittent Hypoxia is 30 drop in SaO2 per hours with a 10% decrease in SaO2.
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
12
October 2008
July 2007   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Healthy subjects

Exclusion Criteria:

  • Any history or significant medical condition
Both
18 Years and older
Yes
Contact information is only displayed when the study is recruiting subjects
France
 
NCT00746928
05-CHUG-23
No
TAMISIER Renaud, University Hospital, Grenoble
University Hospital, Grenoble
Not Provided
Principal Investigator: Renaud Tamisier, MD, PhD University Hospital, Grenoble
University Hospital, Grenoble
September 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP