Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2009 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00745888
First received: September 2, 2008
Last updated: September 4, 2009
Last verified: August 2009

September 2, 2008
September 4, 2009
May 2007
Not Provided
28-day Survival [ Time Frame: 28 days ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00745888 on ClinicalTrials.gov Archive Site
Days stay in ICU Days on ventilator SOFA score Complications [ Time Frame: 28 days ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. There are some questions on the oxidative stress of the critical illness. First, the investigators want to search out the effects of the past history, smoking, alcohol drinking, use of antioxidants, different diseases, and different duration of SIRS on the degree of oxidative stress. Second, besides total count of ROS, the investigators used new techniques to determine superoxide(O2●-), hydrogen peroxide (H2O2), and hypochlorous acid(HOCl). Furthermore, we want to investigate the correlation of the degree of different reactive oxygen species and the severity of SIRS or shock. Third, we try to investigate the correlation between the change of oxidative stress and the prognosis of the patients.

The investigators wish this study will help them to investigate the effect of oxidative stress on critical ill patients, to modulate the oxidative stress, to decrease the occurrence of SIRS, shock, and multiorgan failure, and to improve the long term outcome of patients.

Not Provided
Observational
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:

blood sample

Probability Sample

Patients admitted to surgical ICU

  • Sepsis
  • Shock
Other: Chemiluminescence Analyzer
measure reactive oxygen species
1
age > 18 y/o Patients admitted to surgical ICU
Intervention: Other: Chemiluminescence Analyzer
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
200
Not Provided
Not Provided

Inclusion Criteria:

  • Age > 18 y/o
  • Admitted to surgical ICU

Exclusion Criteria:

  • Patients with brain death
Both
18 Years and older
No
Contact: Yu-Chang Yeh, MD 886-9-68661829 tonyyeh@ntuh.gov.tw
Taiwan
 
NCT00745888
9561709132
No
Yu-Chang Yeh, National Taiwan University Hospital
National Taiwan University Hospital
Not Provided
Principal Investigator: Yu-Chang Yeh National Taiwan University Hospital
National Taiwan University Hospital
August 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP