Comparison of Transfers of Fresh and Thawed Embryos in Patients With Prior Failed Embryo Transfer Cycles

This study has been withdrawn prior to enrollment.
(No recruitment)
Sponsor:
Information provided by:
Fertility Center of Las Vegas
ClinicalTrials.gov Identifier:
NCT00736177
First received: August 13, 2008
Last updated: April 8, 2014
Last verified: February 2009

August 13, 2008
April 8, 2014
August 2008
August 2009   (final data collection date for primary outcome measure)
Ongoing pregnancy with fetal heart motion [ Time Frame: 10 weeks gestation ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00736177 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Comparison of Transfers of Fresh and Thawed Embryos in Patients With Prior Failed Embryo Transfer Cycles
Comparison of Transfers of Fresh and Thawed Embryos in Patients With Prior Failed Embryo Transfer Cycles

This study seeks to determine if patients with a history of failed fresh embryo transfer(s) will have increased success rates with embryo cryopreservation and subsequent thawed embryo transfer when compared to fresh embryo transfer.

Implantation failure remains a significant problem in cycles of in vitro fertilization (IVF). Patients with a history of implantation failure in fresh autologous cycles have been shown have reduced chance of success in subsequent fresh autologous cycles. A potentially frequent cause of implantation failure is reduced endometrial receptivity following ovarian stimulation, perhaps due to the effects of supraphysiologic hormone levels on endometrial development. Therefore, such patients may have a greater chance of success if all of their embryos are cryopreserved for use in a subsequent cycle in which endometrial development can be more carefully controlled, absent the effects of ovarian stimulation. Therefore this study compares success rates in cycles of fresh embryo transfer and cycles with transfer of frozen-thawed embryos.

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
  • Infertility
  • Subfertility
  • Procedure: Embryo cryopreservation
    Subjects in the Test group will have their embryos cryopreserved for transfer in a subsequent cycle.
  • Procedure: Fresh embryo transfer
    Subjects in the Control group will receive fresh embryo transfer.
  • Active Comparator: Control
    Patients in the control group will undergo conventional IVF cycles with fresh blastocyst transfer.
    Intervention: Procedure: Fresh embryo transfer
  • Experimental: Test group
    Patients in the Test group will have their embryos cryopreserved for transfer in a second cycle.
    Intervention: Procedure: Embryo cryopreservation

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Withdrawn
0
August 2009
August 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age 18 to 40 years
  • Cycle day 3 FSH less than 10 IU/l
  • At least 8 antral follicles
  • At least one previous autologous embryo transfer cycle that did not result in ongoing pregnancy at 10 weeks.

Exclusion Criteria:

  • Embryo biopsy
  • Any prior fresh embryo transfer that resulted in live birth
Female
18 Years to 40 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00736177
SAIRB-08-0012
No
Bruce Shapiro, M.D., Medical Director, Fertility Center of Las Vegas
Fertility Center of Las Vegas
Not Provided
Principal Investigator: Bruce Shapiro, M.D. Fertility Center of Las Vegas
Fertility Center of Las Vegas
February 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP