Measurement of Substance P in Saliva of Low Back Pain Patients

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2009 by Kovacs Foundation.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Kovacs Foundation
ClinicalTrials.gov Identifier:
NCT00735735
First received: August 14, 2008
Last updated: June 26, 2011
Last verified: December 2009

August 14, 2008
June 26, 2011
February 2009
January 2012   (final data collection date for primary outcome measure)
Levels of Substance P in the saliva [ Time Frame: 12 months ] [ Designated as safety issue: No ]
Higher levels of Substance P in the saliva of subjects with severe chronic low back pain. [ Time Frame: 12 months ] [ Designated as safety issue: No ]
Complete list of historical versions of study NCT00735735 on ClinicalTrials.gov Archive Site
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Measurement of Substance P in Saliva of Low Back Pain Patients
Study of the Measurement of Substance P in the Saliva of Patients With Low Back Pain

The purpose of this study is to compare the levels of Substance P in saliva, in patients with severe chronic low back pain and in subjects without it. In addition, to explore a possible cutoff point, in order to define normal and pathological levels of Substance P in saliva. The ultimate objective would be to design a measurement method for use in routine clinical practice.

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Interventional
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Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Diagnostic
Low Back Pain
Other: The taking of a saliva sample from each subject.
After taking the sample, the saliva will be transferred via a pipette to a clean tube which will be labeled with the subject's name, the date and the hour. Once a month the tubes will be sent to the collaborating laboratory for analysis.
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
40
June 2012
January 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients referred to the Kovacs Back Pain Unit in Palma de Mallorca for chronic low back pain
  • A pain level of 6 or greater on the PI-NRS scale (0=no pain, 10= worst pain possible)
  • Seen at the Unit between 9 and 13 hours (due to the circadian rhythm of Substance P in saliva and to avoid great variability in the results)

For healthy subjects:

  • Volunteers with no pain (anywhere)
  • That in the past year have had no more than 40 days with pain, and no episode of more than 7 days of continuous pain.

Exclusion Criteria:

  • Subjects with pain that is additional to or different from chronic low back pain
Both
18 Years to 80 Years
Yes
Contact: Francisco M Kovacs, MD, PhD +34 971 720809 kovacs@kovacs.org
Contact: María Teresa Gil del Real, MPH +34 91 3440244 mtgildelreal@kovacs.org
Spain
 
NCT00735735
FK 26
Yes
Francisco M. Kovacs, Director of Scientific Department, Kovacs Foundation
Kovacs Foundation
Not Provided
Study Director: Francisco M Kovacs, MD, PhD Kovacs Foundation, Palma de Mallorca, 07012, Spain
Principal Investigator: Mario Gestoso, MD Kovacs Foundation,Palma de Mallorca, Spain
Kovacs Foundation
December 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP