Association Study of Gene Polymorphisms With Cardiac Performance

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2008 by University Hospital, Essen.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University Hospital, Essen
ClinicalTrials.gov Identifier:
NCT00730899
First received: August 4, 2008
Last updated: NA
Last verified: August 2008
History: No changes posted

August 4, 2008
August 4, 2008
May 2008
January 2011   (final data collection date for primary outcome measure)
genotype dependent change of hemodynamic variables [ Time Frame: one day ] [ Designated as safety issue: No ]
Same as current
No Changes Posted
all cause mortality [ Time Frame: 60 days ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Association Study of Gene Polymorphisms With Cardiac Performance
Observational Association Study of G Protein Polymorphisms With Cardiac Performance in Coronary Artery Disease Patients Undergoing Coronary Artery Bypass Grafting

The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.

G Protein pathways plays a pivotal role in mediating positive inotropy and cardiac hypertrophy by transducing signals of neurohormones in cardiomyocytes. Single nucleotide polymorphisms (SNPs) in the G protein subunits Galphas and Galphaq have been shown to result in altered protein expression. We now want to examine whether G Protein polymorphisms alter NYHA functional class, and hemodynamic variables in patients with coronary artery disease scheduled for coronary artery bypass grafting .

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

whole blood

Non-Probability Sample

Patients with coronary artery disease scheduled for coronary artery bypass grafting in the university hospital

  • Genetic Polymorphism
  • Coronary Artery Disease
  • Hemodynamics
Not Provided
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
500
June 2011
January 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • clinical diagnosis of coronary artery disease
  • patients scheduled for coronary artery bypass grafting

Exclusion Criteria:

  • emergency operation
  • combined vitium
Both
18 Years to 80 Years
No
Contact: Ulrich H Frey, MD +49201723 ext 1401 ulrich.frey@uk-essen.de
Germany
 
NCT00730899
HOT-001
No
Ulrich Frey, University Hospital Essen
University Hospital, Essen
Not Provided
Study Director: Jürgen Peters, MD University Hospital, Essen
University Hospital, Essen
August 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP