Early Exercise Training in Critically Ill Patients

• quadriceps force [ Time Frame: ICU discharge and hospital discharge ] [ Designated as safety issue: No ]
• functional status (Berg Balance Scale, Functional Ambulation Categories, SF-36 Physical Function-item) [ Time Frame: ICU discharge and hospital discharge ] [ Designated as safety issue: No ]

This randomized controlled trial was designed to investigate whether a daily training session using a bedside cycle ergometer, started early in stable critically ill patients with an expected prolonged ICU stay, could induce a beneficial effect on exercise performance, quadriceps force and functional autonomy at ICU and hospital discharge compared to a standard physiotherapy program.

Inactivity during prolonged bed rest leads to muscle dysfunction. Muscle function decreases even faster in ICU patients due to inflammation, pharmacological agents (corticosteroids, muscle relaxants, neuromuscular blockers, antibiotics), and the presence of neuromuscular syndromes, associated with critical illness. A recent recommendation document advices to start early with active and passive exercise in critically ill patients. However, no evidence is available concerning the feasibility of an early muscle training intervention in the acute ICU phase when patients are still under sedation. A rather new method to train bed-bound patients is the use of a bedside cycle ergometer. This randomized controlled trial was designed to investigate whether a daily training session using a bedside cycle ergometer, started early in stable critically ill patients with an expected prolonged ICU stay, could induce a beneficial effect on exercise performance, quadriceps force and functional autonomy at ICU and hospital discharge compared to a standard physiotherapy program.

• Critical Illness
• Intensive Care
• Muscle Weakness
• Deconditioning

• Behavioral: Bedside cycle exercise therapy
  A 20-minute cycling exercise session is performed 5 days a week using a bedside cycle ergometer. Patients can cycle passively and actively against increasing resistance. Besides this, patients receive the standard physiotherapy program as in arm 2
  Other Names:

  • exercise therapy
  • exercise training
  • exercise
  • cycle training
  • cycle exercise
  • Motomed Letto
• Behavioral: Standard physiotherapy program
  The standard physiotherapy program consists of daily chest physiotherapy and a mobilization session on 5 days per week.
  Other Names:

  • Usual physiotherapy
  • Routine physiotherapy
  • Mobilization

• Experimental: 1
  Intervention: Behavioral: Bedside cycle exercise therapy
• Active Comparator: 2
  Intervention: Behavioral: Standard physiotherapy program

Inclusion Criteria:

• ICU stay > 5 days
• Expected prolonged stay of at least 7 more days
• Cardiorespiratory status that allows at least passive exercise therapy

Exclusion Criteria:

• Persistent or progressive neurological or (neuro)muscular disease
• Coagulation disorders (INR > 1.5, [BP] < 50000/mm³)
• Intracranial pressure > 20 mmHg
• Psychiatric disorders or severe confusion