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F18-Flouride PET/CT in Acute Knee Injury

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2008 by Tel-Aviv Sourasky Medical Center.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Tel-Aviv Sourasky Medical Center
ClinicalTrials.gov Identifier:
NCT00687921
First received: May 28, 2008
Last updated: May 30, 2008
Last verified: May 2008

May 28, 2008
May 30, 2008
June 2008
March 2009   (final data collection date for primary outcome measure)
we will refer patients over the age of 18 who had knee trauma, intent to or had MRI assessment and are scheduled for arthroscopy. The compartments of the injured knee will be evaluated on each of the modalities. [ Time Frame: 6 mounth ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00687921 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
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F18-Flouride PET/CT in Acute Knee Injury
F18-Flouride PET/CT in Acute Knee Injury. A Prospective Study

18F-fluoride is a positron-emitting bone-seeking agent with favorable pharmacokinetic properties. Its uptake mechanism resembles that of 99mTc-MDP. After IV administration, 18F-fluoride diffuses through the bone capillaries into the bone extracellular fluid (ECF). Its plasma clearance is more rapid than that of 99mTc-MDP and its single-passage extraction efficiency is higher. The fast blood clearance of 18F-fluoride results in a better target- to- background ratio. Bone uptake of 18F-fluoride is two-fold higher than that of 99mTc-MDP. Combining the favorable pharmacokinetic characteristics of 18F-fluoride with the high performance of PET technology, 18F-fluoride is a valuable imaging modality of the skeleton.

There are only few manuscripts on the role of static 18F-fluoride PET for detection of lesions in patients referred for non-oncologic indications The purpose of the study is to prospectively assess the added value of Fluoride PET/CT in the clinical setting of acute knee injury. The findings of Fluoride PET/CT will be correlated with those found on arthroscopy and MRI which the currently used diagnostic techniques with a high, however, not perfect diagnostic accuracy regarding the issue of bone injury which is a critical component on the long term outcome after knee injury.

We intend to inject only 5mCi of Fluoride, as we already did before, thus reducing the radiation exposure to half of that of the routine Tc-MDP bone scintigraphy.

We will refer 50 patients over the age of 18 who had knee trauma, intent to or had MRI assessment and are scheduled for arthroscopy. The compartments of the injured knee will be evaluated on each of the modalities.

Exclusion criterion is pregnancy

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   None Retained
Description:

not relevant

Probability Sample

patients over the age of 18 who had knee trauma, intent to or had MRI assessment and are scheduled for arthroscopy

Knee Injury
Not Provided
A
patients over the age of 18 who had knee trauma, intent to or had MRI assessment and are scheduled for arthroscopy.
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
50
June 2009
March 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • patients over the age of 18 who had knee trauma

Exclusion Criteria:

  • pregnancy
  • age under 18 years
Both
18 Years to 85 Years
No
Contact: Einat Even-sapir, PhD, MD 972-3-697-3432 evensap@tasmc.health.gov.il
Not Provided
 
NCT00687921
TASMC-08-EE-118-CTIL
Yes
Einat Even-Sapir MD, PhD, Dept of Nuclear Medicine. Tel Aviv Sourasky Medical Center
Tel-Aviv Sourasky Medical Center
Not Provided
Principal Investigator: Einat R. Even-Sapir, MD, PhD Tel-Aviv Sourasky Medical Center
Tel-Aviv Sourasky Medical Center
May 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP