Helicobacter Pylori Empiric Treatment in Ulcer Bleeding (HETUB)

The goal of the study is to compare the effectiveness of empirical Helicobacter pylori treatment compared with treatment depending on diagnostic tests for Helicobacter pylori in patients with Upper gastrointestinal bleeding due to peptic ulcer. Main hypothesis is that empirical treatment will reduce the number of patients lost to follow-up thus improving the cure rates of Hp infection.

• Other: Empirical Hp eradication
  Empirical Helicobacter pylori treatment initiated immediately after oral intake is resumed
  Other Name: Standard Hp eradication treatment
• Other: Eradication treatment guided by a positive test
  Eradication treatment given if there is at least one positive diagnostic test (URT, histological test, breath test or serology) for Helicobacter pylori.
  Other Name: Standard Hp treatment

• Active Comparator: 1
  Empirical eradication treatment
  Intervention: Other: Empirical Hp eradication
• Active Comparator: 2
  Eradication treatment according to a diagnostic test (URT, histological test, breath test or serology).
  Intervention: Other: Eradication treatment guided by a positive test

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Inclusion Criteria:

• Patients older than 18.
• Informed Consent signed.
• Diagnosis of no variceal upper gastrointestinal bleeding secondary to a duodenal ulcer, erosive duodenitis or gastric ulcer.
• Life expectancy longer than 6 months.
• Able to attend further clinical controls.
• Absence of the following exclusion criteria.

Exclusion Criteria:

• Previous eradication treatment.
• Use of antibiotics 2 weeks prior to inclusion.
• Need for Antisecretor treatment that cannot be stopped to perform the breath test.
• Pregnancy or breastfeeding.

• Corporacion Parc Tauli
• Centro de Investigación Biomédica en Red