Long-Term Outcomes of Alternative Brachytherapy Techniques for Early Prostate Cancer

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2010 by Massachusetts General Hospital.
Recruitment status was  Recruiting
Sponsor:
Collaborators:
Dana-Farber Cancer Institute
Brigham and Women's Hospital
Beth Israel Deaconess Medical Center
Metro West Medical Center
Information provided by:
Massachusetts General Hospital
ClinicalTrials.gov Identifier:
NCT00681694
First received: May 19, 2008
Last updated: April 27, 2010
Last verified: April 2010

May 19, 2008
April 27, 2010
March 2002
March 2011   (final data collection date for primary outcome measure)
To assess changes in generic and disease specific quality of life over time after treatment with brachytherapy for early prostate cancer [ Time Frame: 10 years ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00681694 on ClinicalTrials.gov Archive Site
  • To compare these outcomes after two alternative brachytherapy techniques, standard ultrasound guided brachytherapy and MRI guided prostate brachytherapy (MRIGPB) [ Time Frame: 10 years ] [ Designated as safety issue: No ]
  • To identify factors associated with specific adverse outcomes. [ Time Frame: 10 years ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Long-Term Outcomes of Alternative Brachytherapy Techniques for Early Prostate Cancer
Long-Term Outcomes of Alternative Brachytherapy Techniques for Early Prostate Cancer

The purpose of this research study is to assess outcomes of treatment for early prostate cancer. Current treatments for early (non-metastatic) cancer may cause long-term impairments in the patients quality of life. In this study we will compare the outcomes of patients treated with two alternative brachytherapy (seed implants) techniques using a series of questionnaires.

Participants will be asked to complete a questionnaire about their health prior to treatment, at 1, 3 and 12 months after treatment and then once a year 4 more times.

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample

Patients who have indicated their intention to receive brachytherapy at one of the four accrual sites.

Prostate Cancer
  • Radiation: brachytherapy
    An experimental arm using MRI imaging and excluding the transition zone from the target volume
  • Radiation: brachytherapy
    Standard ultrasound-guided brachytherapy with standard target volumes
  • MRBT
    MRI-assisted brachytherapy, the experimental arm
    Intervention: Radiation: brachytherapy
  • USBT1
    Standard ultrasound-guided brachytherapy performed by group 1 (control arm 1)
    Intervention: Radiation: brachytherapy
  • USBT2
    Standard ultrasound-guided brachytherapy performed by group 2 (control group 2)
    Intervention: Radiation: brachytherapy
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
414
March 2011
March 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Pathological diagnosis of an adenocarcinoma of the prostate
  • 18 years of age or older
  • Prior choice of either standard brachytherapy or MRIGPB as primary treatment

Exclusion Criteria:

  • Prior primary therapy (surgery or external beam radiation) for prostate cancer
  • Current hormone ablation therapy
Male
18 Years and older
No
Contact: James Talcott, MD, SM 617-724-5451 jtalcott@partners.org
Contact: Anita Rodrigues aerodrigues@partners.org
United States
 
NCT00681694
01-264
Yes
James Talcott, MD, SM, Massachusetts General Hospital
Massachusetts General Hospital
  • Dana-Farber Cancer Institute
  • Brigham and Women's Hospital
  • Beth Israel Deaconess Medical Center
  • Metro West Medical Center
  • Department of Defense
Principal Investigator: James Talcott, MD, SM Massachusetts General Hospital
Massachusetts General Hospital
April 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP