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Bronchospasm Associated With High Nitric Oxide

This study has been completed.
Sponsor:
Information provided by:
University of Sao Paulo
ClinicalTrials.gov Identifier:
NCT00666510
First received: April 23, 2008
Last updated: NA
Last verified: April 2008
History: No changes posted

April 23, 2008
April 23, 2008
January 1999
Not Provided
Exhaled nitric oxide in parts per billion [ Time Frame: one to six months after surgery ] [ Designated as safety issue: No ]
Same as current
No Changes Posted
Eosinophils concentration within sputum sample, pulmonary function tests [ Time Frame: one to six months after surgery ] [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Bronchospasm Associated With High Nitric Oxide
Higher Exhaled Nitric Oxide (NO) is Associated With Intraoperative Bronchospasm

Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.

Previous studies in asthmatic patients suggested that exhaled nitric oxide may represent a noninvasive measure for airway inflammation. Anesthesia information forms from 1999 throughout 2004 were revised (n=146.358). Bronchospasm occurrence appeared registered on 863 forms. From those, nine were identified as non-asthmatics patients (Bronchospasm group). Also, 12 asthmatics constituted one additional group (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to Exhaled nitric oxide measurements (parts/billion), spirometry and induced sputum.
Observational
Observational Model: Case Control
Time Perspective: Retrospective
Not Provided
Retention:   Samples Without DNA
Description:

Sputum
Non-Probability Sample

Hospital, late post-anesthesia cared patients
  • Asthma
  • Airway Hyperresponsiveness
Not Provided
  • Bronchospasm
    Patients who presented bronchospasm during anesthesia induction
  • Asthma
    Patients who presented bronchospasm during anesthesia induction and were identified as asthmatics
  • Control
    Patients who were submitted to anesthesia induction and showed no complications
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
31
December 2004
Not Provided

Inclusion Criteria:

  • patients with no systemic disease and registered bronchospasm during anesthesia induction

Exclusion Criteria:

  • hypertension, COPD, diabetes, pregnancy
Both
16 Years to 65 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Brazil
 
NCT00666510
CAP125-01
No
Joaquim Edson Vieira, Fisiopatologia Experimental FMUSP
University of Sao Paulo
Not Provided
Principal Investigator: Joaquim E Vieira, MD, PhD University of Sao Paulo Medical School - FMUSP
University of Sao Paulo
April 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP