Pharmacology and Physiology of the Lower Urinary Tract

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2008 by University College London Hospitals.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University College London Hospitals
ClinicalTrials.gov Identifier:
NCT00662064
First received: April 16, 2008
Last updated: June 19, 2008
Last verified: June 2008

April 16, 2008
June 19, 2008
February 2002
December 2008   (final data collection date for primary outcome measure)
Immunohistochemistry + PCR of bladder tissue [ Time Frame: not specified (storage of biopsies) ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00662064 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Pharmacology and Physiology of the Lower Urinary Tract
Pharmacology and Physiology of the Lower Urinary Tract

The function of the lower urinary tract is simple - urine storage and voiding. However, despite this simplicity of function, the control of the lower urinary tract is a rather complex, multilevel process (urothelium, detrusor, peripheral nerves, spinal cord and higher cerebral centres) and the mechanisms involved remain poorly elucidated.

This study is designed to gain a more in depth understanding of the lower urinary tract function. Using bladder biopsies, tissue staining for characteristic markers present on nerves and other cells will be performed. We hypothesize that certain markers are altered in disease and turn back towards the control level of healthy people or patients with successful medical treatment.

Not Provided
Observational
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:

bladder biopsies from patients with lower urinary tract dysfunction and from healthy controls

Non-Probability Sample

Patients with lower urinary tract dysfunction and controls with normal lower urinary tract function

Urologic Diseases
Not Provided
  • 1
    Patients with lower urinary tract dysfunction
  • 2
    Controls with normal lower urinary tract function
Roosen A, Datta SN, Chowdhury RA, Patel PM, Kalsi V, Elneil S, Dasgupta P, Kessler TM, Khan S, Panicker J, Fry CH, Brandner S, Fowler CJ, Apostolidis A. Suburothelial myofibroblasts in the human overactive bladder and the effect of botulinum neurotoxin type A treatment. Eur Urol. 2009 Jun;55(6):1440-8. Epub 2008 Nov 18.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
200
December 2008
December 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients with lower urinary tract dysfunction
  • Controls with normal lower urinary tract function

Exclusion Criteria:

  • Age < 18 years old
  • Pregnancy
Both
18 Years and older
Yes
Contact: Thomas M Kessler, MD 44-207-829-8713 ext 8713 tkessler@gmx.ch
Contact: Shahid Khan, MD 44-207-829-8713 ext 8713 drshahidkhan@gmail.com
United Kingdom
 
NCT00662064
00/0039
No
Prof C J Fowler, Prof C H Fry, Dep Uro-Neurology, National Hospital for Neurology and Neurosurgery, London, UK
University College London Hospitals
Not Provided
Principal Investigator: Clare J Fowler, FRCP Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK
Principal Investigator: Suzy Elneil, PhD, MRCOG Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK
University College London Hospitals
June 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP