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| Descriptive Information Fields | |||||||||
| Brief Title † | Is Pentoxifylline Able to Improve Olfactory Sensitivity? | ||||||||
| Official Title † | Agapurin Retard Used in Patients With Smell Disorder- A Post-Marketing Observational Study | ||||||||
| Brief Summary | Signal processing in the olfactory neuron could be influenced by inhibition of enzymes like phosphodiesterase. Pentoxifylline is a unspecific phosphodiesterase inhibitor. The hypothesis is that pentoxifylline could lead to increased sensitivity to odors. |
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| Detailed Description | Olfactory signal processing is conducted by a G-protein linked increase of intracellular concentration of adenosine 3´,5´-cyclic monophosphate (cAMP). In the cilia of olfactory sensory neurons (OSN) cAMP is degraded by phosphodiesterase 1C2 (PDE1C2). Inhibition of PDE1C2 could result in an increased response of OSN to chemical stimuli. Aim of the present prospective post-marketing surveillance study was to investigate the impact of pentoxifylline, an unspecific phosphodieasterase inhibitor, on olfactory function. |
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| Study Phase | |||||||||
| Study Type † | Observational | ||||||||
| Study Design † | Other, Prospective | ||||||||
| Primary Outcome Measure † | TDI-score [ Time Frame: at day 0 and follow up after 3 weeks ] [ Designated as safety issue: No ] | ||||||||
| Secondary Outcome Measure † | odor threshold odor discrimination odor identification [ Time Frame: at day 0 and at follow up after 3 weeks ] [ Designated as safety issue: No ] | ||||||||
| Condition † | Olfaction Disorders | ||||||||
| Intervention † | Drug: Pentoxifylline retard 400mg | ||||||||
| MEDLINE PMIDs | |||||||||
| Links | |||||||||
| Recruitment Information Fields | |||||||||
| Recruitment Status † | Recruiting | ||||||||
| Enrollment † | 30 | ||||||||
| Start Date † | November 2007 | ||||||||
| Completion Date | November 2009 | ||||||||
| Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
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| Gender | Both | ||||||||
| Ages | 18 Years to 50 Years | ||||||||
| Accepts Healthy Volunteers | No | ||||||||
| Contacts †† |
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| Location Countries † | Germany | ||||||||
| Administrative Information Fields | |||||||||
| NCT ID † | NCT00660868 | ||||||||
| Organization ID | EK157072007 | ||||||||
| Secondary IDs †† | |||||||||
| Study Sponsor † | Dresden University of Technology | ||||||||
| Collaborators †† | |||||||||
| Investigators † |
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| Information Provided By | Dresden University of Technology | ||||||||
| Verification Date | April 2008 | ||||||||
| First Received Date † | April 16, 2008 | ||||||||
| Last Updated Date | April 16, 2008 | ||||||||
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