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Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2008 by Soroka University Medical Center.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Soroka University Medical Center
ClinicalTrials.gov Identifier:
NCT00660465
First received: April 15, 2008
Last updated: November 9, 2014
Last verified: February 2008

April 15, 2008
November 9, 2014
May 2008
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Complete list of historical versions of study NCT00660465 on ClinicalTrials.gov Archive Site
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Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises
Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises .

The purpose of this study is to explore how arterial PaCO2 effect regional Blood Oxygen Level Dependent (BOLD) signal, and indirectly the brain regional O2 level .

Among many parameters effecting cerebral blood flow(CBF), partial pressure of CO2 (PaCO2) in arterial blood has a significant effect. A small increase in arterial PaCO2 level will cause a significant increase of CBF , followed by increase of O2 level . The main objective is to explore the effect of arterial PaCO2 level on regional CBF and brain O2 level, by using breathing exercises to modulate arterial PaCO2. The regional Blood Oxygen Level Dependent (BOLD) signal produced by MRI , will indicate the regional O2 level.

Observational
Observational Model: Case-Only
Time Perspective: Cross-Sectional
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Non-Probability Sample

residents

Healthy
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A18
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Not yet recruiting
6
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Inclusion Criteria:

  • adults over 18 years old .

Exclusion Criteria:

  • under 18 years old.
  • Artificial pacemaker
  • implantable cardioverter-defibrillator (ICD)
  • Hearing aid, implantable or portable.
  • artificial heart valve
  • Surgical clips
  • Metal fragments in eyes
  • Electronic stimulators
  • Implanted pumps
  • Implantable Neurostimulation Device
  • metal fragments of any sort
  • Permanent makeup or tattoo
  • transfusion pump
  • pregnant or breast feeding women
  • False teeth , retainer or dental crown
Both
18 Years to 75 Years
Yes
Contact: Alexander Gersten, Ph.D +972-52-3906012 alex.gersten@gmail.com
Israel
 
NCT00660465
SOR467608CTIL
No
Alexander Gersten, Ben-Gurion University of the Negev
Soroka University Medical Center
Not Provided
Study Director: Ilan Shelef, M.D Head, Neuroradiolgy Unit ;Department of Diagnostic Imaging ;Soroka Univrsity Medical Center
Soroka University Medical Center
February 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP