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The Effect of Intravenous Lidocaine on Allodynia

This study is not yet open for participant recruitment.
Study NCT00659633.   Last updated on April 14, 2008.   Information provided by University of Alabama at Birmingham

This Tabular View shows the required WHO registration data elements as marked by †

Descriptive Information Fields
Brief Title † The Effect of Intravenous Lidocaine on Allodynia
Official Title † The Effect of Intravenous Lidocaine on Allodynia (Carl Koller Grant)
Brief Summary

The purpose of this study is to study if lidocaine, given intravenously, reduces pain.
Detailed Description

Clinicians use lidocaine intravenously in a fashion that suggests that it might have analgesic effects. Therefore, we test the hypothesis that lidocaine reduces pain intensity in response to experimental pain.
Study Phase
Study Type † Interventional
Study Design † Treatment, Open Label, Dose Comparison, Single Group Assignment, Efficacy Study
Primary Outcome Measure † Pain intensity [ Time Frame: before, during, and after intravenous lidocaine ] [ Designated as safety issue: No ]
Secondary Outcome Measure †
Condition † Pain
Intervention † Drug: lidocaine
MEDLINE PMIDs
Links
Recruitment Information Fields
Recruitment Status † Not yet recruiting
Enrollment † 10
Start Date † December 2008
Completion Date
Eligibility Criteria †

Inclusion Criteria:

  • Chronic Regional Pain Syndrome diagnostic criteria by the Work Safe BC. vi

Exclusion Criteria:

  • History of Substance abuse
  • Other Medications: CRPS patients are expected to be treated for chronic pain, whether the current treatment regimen interferes with sensory motor testing will be determined on a case by case basis.
  • Coronary Artery Disease (CAD): unstable
  • Congestive Heart Failure (CHF): unstable
  • Heart Arrhythmia: symptomatic
  • Chronic Obstructive Pulmonary Disease (COPD)
  • Lidocaine Allergy
  • Diagnostic and Statistical Manual of Mental Disorders (Rev IV): Axis I: Common Axis I disorders include depression, anxiety disorders, bipolar disorder, ADHD, and schizophrenia. Axis II: borderline personality disorder, schizotypal personality disorder, antisocial personality disorder, and mild mental retardation.
  • Presence of Contraindications for MRI
  • Presence of electronically, magnetically, and mechanically activated implants
  • Electronically, magnetically, and mechanically activated implants
  • Ferromagnetic or electronically operated active devices like automatic cardioverter defibrillators
  • Cardiac pacemakers
  • Metallic splinters in the eye
  • Ferromagnetic haemostatic clips in the central nervous system (CNS)
  • Claustrophobia
  • Pregnancy
Gender Both
Ages 19 Years and older
Accepts Healthy Volunteers No
Contacts ††
Contact: Debbie Owen, BS     205-975-2088     debbieo@uab.edu    
Contact: Jeff Worrell, RN, BSN, MPPM     205-975-2098     jworrell@uab.edu    
Location Countries † United States
Administrative Information Fields
NCT ID † NCT00659633
Organization ID F061204014
Secondary IDs ††
Study Sponsor † University of Alabama at Birmingham
Collaborators †† American Society of Regional Anesthesia
Investigators †
Principal Investigator:     Michael Froelich, MD, MS     University of Alabama at Birmingham    
Information Provided By University of Alabama at Birmingham
Verification Date April 2008
First Received Date † April 14, 2008
Last Updated Date April 14, 2008

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.

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