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| Descriptive Information Fields | |||||||||
| Brief Title † | Study of Memantine to Treat Huntington's Disease | ||||||||
| Official Title † | A Pilot Study of Memantine for Cognitive and Behavioral Dysfunction in Huntington's Disease" | ||||||||
| Brief Summary | To determine if memantine in doses of 10 mg BID affects memory, cognition, and behavior in patients with Huntington's disease (HD). |
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| Detailed Description | Results of several published clinical trials suggest that memantine has a beneficial effect in dementing conditions, such as Alzheimer's disease; however, the effects of memantine on cognitive and behavioral function in HD are unknown. Our hypotheses are that HD patients who are administered memantine will show improved performance on psychometric tests of memory and executive functions in addition to behavior and that patients treated with memantine will show more improvement after six months than after three months of treatment. |
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| Study Phase | Phase IV | ||||||||
| Study Type † | Interventional | ||||||||
| Study Design † | Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Crossover Assignment, Safety/Efficacy Study | ||||||||
| Primary Outcome Measure † | sensitive neuropsychological battery [ Time Frame: three months and six months of treatment ] [ Designated as safety issue: No ] | ||||||||
| Secondary Outcome Measure † | behavioral and functional measures at three and six months of treatment [ Time Frame: three and six months of treatment ] [ Designated as safety issue: No ] | ||||||||
| Condition † | Huntington's Disease | ||||||||
| Intervention † | Drug: Memantine | ||||||||
| MEDLINE PMIDs | |||||||||
| Links | |||||||||
| Recruitment Information Fields | |||||||||
| Recruitment Status † | Recruiting | ||||||||
| Enrollment † | 60 | ||||||||
| Start Date † | |||||||||
| Completion Date | |||||||||
| Eligibility Criteria † | Inclusion Criteria:
Exclusion Criteria:
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| Gender | Both | ||||||||
| Ages | 18 Years and older | ||||||||
| Accepts Healthy Volunteers | No | ||||||||
| Contacts †† |
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| Location Countries † | United States | ||||||||
| Administrative Information Fields | |||||||||
| NCT ID † | NCT00652457 | ||||||||
| Organization ID | MEM-HD | ||||||||
| Secondary IDs †† | |||||||||
| Study Sponsor † | University of California, San Diego | ||||||||
| Collaborators †† | Forest Laboratories | ||||||||
| Investigators † | |||||||||
| Information Provided By | University of California, San Diego | ||||||||
| Verification Date | March 2008 | ||||||||
| First Received Date † | March 31, 2008 | ||||||||
| Last Updated Date | March 31, 2008 | ||||||||