Study to Evaluate Changes in Limb Fat When Switching From a Thymidine Analogue (RAVE)

This study has been completed.
Sponsor:
Information provided by:
Gilead Sciences
ClinicalTrials.gov Identifier:
NCT00647946
First received: March 27, 2008
Last updated: June 27, 2008
Last verified: June 2008

March 27, 2008
June 27, 2008
February 2003
October 2004   (final data collection date for primary outcome measure)
Change in total limb fat mass by DEXA scan [ Time Frame: 24 and 48 weeks ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00647946 on ClinicalTrials.gov Archive Site
  • Change in VAT by single slice L4 abdominal CT scan [ Time Frame: 24 and 48 weeks ] [ Designated as safety issue: No ]
  • Change in viral load measurements and CD4 cell count [ Time Frame: 24 and 48 Weeks ] [ Designated as safety issue: No ]
  • Change in fasting cholesterol and triglycerides [ Time Frame: 24 and 48 Weeks ] [ Designated as safety issue: No ]
  • Change in blood insulin and fasting glucose [ Time Frame: 24 and 48 Weeks ] [ Designated as safety issue: No ]
  • Change in blood lactate and anion gap [ Time Frame: 24 and 48 Weeks ] [ Designated as safety issue: No ]
  • Change in bone mineral density by DEXA scan [ Time Frame: 24 and 48 Weeks ] [ Designated as safety issue: No ]
  • Incidence of adverse events [ Time Frame: Upto 48 weeks ] [ Designated as safety issue: No ]
  • Change in VAT by single slice L4 abdominal CT scan [ Time Frame: 24 and 48 weeks ] [ Designated as safety issue: No ]
  • Change in viral load measurements and CD4 cell count [ Time Frame: 24 and 48 Weeks ] [ Designated as safety issue: No ]
  • Change in fasting cholesterol and tryglycerides [ Time Frame: 24 and 48 Weeks ] [ Designated as safety issue: No ]
  • Change in blood insulin and fasting glucose [ Time Frame: 24 and 48 Weeks ] [ Designated as safety issue: No ]
  • Change in blood lactate and anion gap [ Time Frame: 24 and 48 Weeks ] [ Designated as safety issue: No ]
  • Change in bone mineral density by DEXA scan [ Time Frame: 24 and 48 Weeks ] [ Designated as safety issue: No ]
  • Incidence of adverse events [ Time Frame: Upto 48 weeks ] [ Designated as safety issue: No ]
Not Provided
Not Provided
 
Study to Evaluate Changes in Limb Fat When Switching From a Thymidine Analogue
A Phase II, Open-Label, Multicentre, Randomised, Comparator Study of Substitution With Tenofovir or Abacavir in HIV-1 Infected Individuals, With a Viral Load < 50 Copies/mL, Receiving a Thymidine Analogue (Zidovudine or Stavudine) as Part of Their Highly Active Antiretroviral Therapy (HAART)

A previous study substituting zidovudine or stavudine to abacavir in patients with severe or moderate lipoatrophy has shown an increase in limb fat by DEXA. This study was conducted over a 24-week period and although improved outcomes were documented by objective measures, DEXA scans, subjective observation did not correspond. Longer-term follow up of these patients is required.

This 48 week study is designed to compare the substitution of the thymidine analogues zidovudine (ZDV) or stavudine (D4T) with either tenofovir DF or abacavir, in patients treated with highly active antiretroviral therapy (HAART), and show improved outcomes on total limb fat mass, improved body shape by dual energy x-ray absorptiometry (DEXA) and computed tomography (CT) scans and improved cholesterol and triglycerides.

This is a phase II, open-label, multicentre, randomised, two-arm study of 48 weeks duration. One hundred HIV infected individuals who have documented lipodystrophy at > 1 body/facial site and currently receiving zidovudine (ZDV) or stavudine (d4T) will be recruited.

Interventional
Phase 2
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Lipodystrophy
  • Drug: tenofovir DF
    tenofovir DF 300mg once daily along with the other antiviral drugs
  • Drug: abacavir 300mg twice daily
    abacavir 300mg twice daily along with the other antiviral drugs
  • Experimental: A
    Stop zidovudine (ZDV) or stavudine (d4T) and start tenofovir DF 300mg once daily along with the other antiviral drugs that are used as part of their HAART regimen
    Intervention: Drug: tenofovir DF
  • Active Comparator: B
    Stop zidovudine (ZDV) or stavudine (d4T) and start abacavir 300mg twice daily along with the other antiviral drugs that are used as part of their HAART regimen
    Intervention: Drug: abacavir 300mg twice daily
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
100
February 2006
October 2004   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Subjects who are male or female > 18 years of age
  • Subjects who are HIV-1 infected as documented by a licensed HIV-1 antibody ELISA
  • Female subjects of childbearing potential must have a negative serum pregnancy test (beta-HCG) within 28 days of trial day 1. Women of childbearing potential must agree to use a barrier method of contraception
  • Female subjects must not be pregnant or lactating
  • Subjects who in the opinion of the investigator have the ability to understand and provided written informed consent to participate in the trial
  • Subjects who in the opinion of the investigator have clinical lipoatrophy at > 1 body/facial site
  • Subjects currently receiving nucleoside analogue regimen including stavudine (d4T) or zidovudine (ZDV)
  • Subjects who are stable on current therapy for >16 weeks
  • Subjects with no prior exposure to tenofovir, abacavir, or adefovir
  • Subjects with no known K65R, 69S mutations or 3 or more thymidine analogue mutations
  • Subjects with documented viral load <50 copies/ml on 2 consecutive occasions including most recent clinic attendance

Exclusion Criteria:

  • Subjects who in the investigator's opinion are unlikely to complete the 48 week trial period
  • Currently active opportunistic disease or documented wasting syndrome
  • Currently receiving chemotherapy for malignancy
  • Subjects who in the opinion of the investigator are unlikely to retain viral response after switching based on treatment or transmission history
  • Currently receiving an insulin sensitising agent (glitazone or metformin)
  • Anabolic steroids in the last 16 weeks other than testosterone at replacement doses (<250mg/2 weekly)
  • Growth hormone use in the last 16 weeks
  • Statin therapy (HMG CoA reductase inhibitor) commenced in the last 16 weeks (patients stable on statins my be included)
  • Current alcohol or illicit drug use which, in the opinion of the investigator, may interfere with the subjects' ability to comply with the dosing schedule and protocol evaluations
  • Receiving concurrent medications that - in the opinion of the investigator and according to drug product labelling - will result in clinically significant interactions with tenofovir or abacavir
  • Pregnant or breast feeding
  • Previously received more than 3 months zidovudine monotherapy
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT00647946
GS-UK-104-1008
No
Geoff Cotton, Medical Monitor, Gilead Sciences
Gilead Sciences
Not Provided
Study Director: Geoff Cotton Gilead Sciences
Gilead Sciences
June 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP