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Diagnostic Value of Procalcitonin in Patients With Acute Appendicitis

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Michael Sand, Ruhr University of Bochum
ClinicalTrials.gov Identifier:
NCT00630071
First received: February 26, 2008
Last updated: October 15, 2012
Last verified: October 2012

February 26, 2008
October 15, 2012
February 2008
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Complete list of historical versions of study NCT00630071 on ClinicalTrials.gov Archive Site
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Diagnostic Value of Procalcitonin in Patients With Acute Appendicitis
A Prospective Study Investigating the Diagnostic Value of Procalcitonin in Patients With Acute Appendicitis

The values of laboratory examinations which are useful for the diagnoses of acute appendicitis are white blood cell count (WBC), C-reactive protein (CRP) and erythrocyte blood sedimentation rate (ESR). Another laboratory value which has recently received considerable attention for the early diagnosis of bacterial infection and sepsis is pro-calcitonin (PCT). In recent studies it has been clearly shown that PCT is one of the most important biochemical indicators which closely correlates with the severity of inflammatory host response to microbial infections. Aim of this open, prospective study is therefore to investigate if PCT has an accurate diagnostic value for the diagnosis of acute appendicitis.

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Observational
Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:

1.5 ml whole blood

Non-Probability Sample

Surgical Emergency Room

Appendicitis
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Sand M, Trullen XV, Bechara FG, Pala XF, Sand D, Landgrafe G, Mann B. A prospective bicenter study investigating the diagnostic value of procalcitonin in patients with acute appendicitis. Eur Surg Res. 2009;43(3):291-7. Epub 2009 Aug 7.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
103
August 2008
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Inclusion Criteria:

  • Clinical diagnosis of appendicitis

Exclusion Criteria:

  • Antibiotic therapy
  • Infection at other body sites
  • Age < 14 years
  • Appendectomy in the medical history
Both
14 Years and older
No
Contact information is only displayed when the study is recruiting subjects
Germany
 
NCT00630071
PCT 01
Yes
Michael Sand, Ruhr University of Bochum
Ruhr University of Bochum
Not Provided
Study Chair: Benno Mann, PD Dr. med. Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum
Principal Investigator: Michael Sand, Dr. med. Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum
Ruhr University of Bochum
October 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP