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Advanced MRI in Major Depression

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00613912
First received: January 31, 2008
Last updated: November 18, 2011
Last verified: November 2011
History of Changes

January 31, 2008
November 18, 2011
March 2008
December 2009   (final data collection date for primary outcome measure)
Differences in morphological and functional cerebral MRI findings in patients suffering from major depression [ Time Frame: 6 months from first MRI in each patient ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00613912 on ClinicalTrials.gov Archive Site
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Advanced MRI in Major Depression
Advanced MRI at 3T for the Evaluation of Ambulant Patients With Major Depression

Depression is the most common psychiatric disorder.

  • 3-5% of a given population has major depression.
  • Less than 50% of the depressed in Denmark are diagnosed with major depression.
  • 25-50% of the depressed have a relative with major depression-underlying brain pathology?

The purpose of this study is to use MRI to evaluate cerebral morphology and function in ambulant patients with major depression

Previous studies within major depression, have often included hospitalized patients with severe symptoms and imaging have been performed with PET and SPECT, which uses ionizing radiation. This study focus on ambulant patients(with or without medication/ECT treatment), to find patients in an earlier stage. Cerebral perfusion with the MR sequence Arterial Spin Labelling, concentrations of different metabolites with MR spectroscopy and brain volumetry with BRAVO 3D T1 ax will be performed.

MR protocol: T2 sag, T2 FLAIR ax, ASL ax, MRS and 3D T1 ax. Scan time 45 min.
Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Non-Probability Sample

Ambulant patients with major depression, selected from the Department of Psychatry, Aalborg hospital-Århus University Hospital.
Depressive Disorder, Major
Other: Magnetic Resonance Imaging
  • Morphological sequences
  • Arterial Spin Labelling (Perfusion)
  • Spectroscopy: anterior cingulate cortex Naa, Cho, Cr, Myo-inositol, glutamate TE 30 Reference voxel in Parietal white matter
Other Name: 3 Tesla GE Scanner HDx
A
Ambulant patients with major depression
Intervention: Other: Magnetic Resonance Imaging
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
49
June 2011
December 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patients who fulfil ICD-10´s criteria for major depression, found within the ambulant psychiatric sector and who has a HAM-D ≥ 18

Exclusion Criteria:

  • If the patient has pacemaker or other magnetic devices
  • Pregnancy
  • Has had an operation in the brain
  • bipolar disorder
Both
20 Years to 65 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Denmark
 
NCT00613912
AUFF-2005-740-004
Yes
University of Aarhus
University of Aarhus
Not Provided
Principal Investigator: Elna-Marie B Larsson, Professor Uppsala University Hospital
University of Aarhus
November 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP