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PET Imaging Study of Recovered Anorexics
This study is ongoing, but not recruiting participants.
Study NCT00603018   Information provided by University of Pittsburgh
First Received: October 16, 2007   Last Updated: September 29, 2009   History of Changes

October 16, 2007
September 29, 2009
June 2007
December 2008   (final data collection date for primary outcome measure)
serotonin level [ Time Frame: 8 weeks ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00603018 on ClinicalTrials.gov Archive Site
 
 
 
PET Imaging Study of Recovered Anorexics
PET Imaging of Dopaminergic Transmission and Serotonin Markers in Anorexia Nervosa

Several studies in the past suggest that individuals who have or had anorexia nervosa may have alterations in brain serotonin. Serotonin seems to play an important role in regulating anxiety, mood, and other symptoms found in anorexia nervosa. We will be using a technology called Positron Emission Tomography (PET), which is a method used to take pictures of the body, in this case, the brain. Study participants will undergo two baseline PET scans on the first day of the study. They will then be given a medication called fluoxetine (also know as Prozac) to take for 8 weeks. At the end of the 8th week, they will return for a third PET scan. By comparing the brain scans, before and after fluoxetine treatment, we can understand more about how treatment with fluoxetine affects the serotonin receptors in the brain. We will be comparing brain serotonin system in women who have recovered from anorexia with healthy control women who have never had an eating disorder in order to gain a better understanding of changes in the serotonin system associated with eating disorders. This study may help shed light on how to make fluoxetine a more effective treatment for anorexia nervosa.

 
 
Interventional
Basic Science, Open Label, Parallel Assignment
Anorexia Nervosa
Drug: Fluoxetine
Other: Recovered anorexia
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Active, not recruiting
120
December 2008
December 2008   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Recovered from Anorexia Nervosa
  • Not taking medication for emotional problems
  • Regular menstrual cycle

Exclusion Criteria:

  • Women who are pregnant or nursing
  • Psychoactive medications in the past 30 days
  • Neurological disorders.
Female
18 Years to 45 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00603018
Walter Kaye, MD, University of Pittsburgh Medical Center
PRO06110005
University of Pittsburgh
National Institute of Mental Health (NIMH)
Principal Investigator: Walter Kaye, M.D. UPMC
University of Pittsburgh
October 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP