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Low-Dose Chest Computed Tomography Screening for Lung Cancer in Survivors of Hodgkin's Disease

This study is currently recruiting participants.
Study NCT00601146.   Last updated on January 15, 2008.   Information provided by Dana-Farber Cancer Institute

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Descriptive Information Fields
Brief Title  Low-Dose Chest Computed Tomography Screening for Lung Cancer in Survivors of Hodgkin's Disease
Official Title  Low-Dose Chest Computed Tomography Screening for Lung Cancer in Survivors of Hodgkin's Disease
Brief Summary

This research study is being done because patients with a history of chest radiation treatment for Hodgkin's disease have been shown to be at increased risk for developing lung cancer a number of years out from treatment. The risk appears to be further increased among patients with a smoking history. Currently, the practice is to recommend annual low-dose chest CT scans in survivors of Hodgkin's disease who have received prior chest radiation treatment and who have at least a moderate smoking history. In this study, the CT scans will be read and interpreted by the study radiologist, and the results recorded in a consistent manner.

Detailed Description

- Participants will undergo a chest computed tomography (CT) scan once a year for a 3-year period.

Study Phase
Study Type  Observational
Study Design  Case-Only, Prospective
Primary Outcome Measure  To prospectively collect data on chest CT screening for patients at increase lung-cancer risk after Hodgkin's disease. [ Time Frame: 3 years ] [ Designated as safety issue: No ]
Secondary Outcome Measure 
Condition  Lung Cancer
Intervention  Procedure: chest computed tomography scan
MEDLINE PMIDs
Links
Recruitment Information Fields
Recruitment Status  Recruiting
Enrollment  200
Start Date  November 2006
Completion Date
Eligibility Criteria 

Inclusion Criteria:

  • 5 years or longer from initial Hodgkin's disease diagnosis
  • Current age 18 or older
  • Received mediastinal irradiation and/or alkylating-agent based chemotherapy
  • Smoking history of 10-pack years or more, or current smoker
  • Pre-approval from the participant's insurance company for the CT study

Exclusion Criteria:

  • Patients with a history of lung cancer
  • Currently receiving treatment for another cancer diagnosis
  • Known diagnosis of any metastatic cancer
  • Pregnant women
Gender Both
Ages 18 Years and older
Accepts Healthy Volunteers No
Contacts ††
Contact: Andrea K. Ng,, MD     617-732-7361        
Location Countries  United States
Administrative Information Fields
NCT ID  NCT00601146
Organization ID 06-122
Secondary IDs ††
Study Sponsor  Dana-Farber Cancer Institute
Collaborators †† Brigham and Women's Hospital
Investigators 
Principal Investigator:     Andrea K. Ng, MD     Dana-Farber Cancer Institute/Brigham and Women's Hospital    
Information Provided By Dana-Farber Cancer Institute
Verification Date January 2008
First Received Date  January 15, 2008
Last Updated Date January 15, 2008

 †    Required WHO trial registration data element.
††   WHO trial registration data element that is required only if it exists.




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