Cetuximab and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot Be Removed by Surgery

This study has been completed.
Sponsor:
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00599833
First received: January 11, 2008
Last updated: June 25, 2013
Last verified: August 2009

January 11, 2008
June 25, 2013
May 2007
September 2010   (final data collection date for primary outcome measure)
Progression-free survival rate at 6 months [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00599833 on ClinicalTrials.gov Archive Site
  • Response rate by RECIST criteria [ Designated as safety issue: No ]
  • Toxicity by NCI CTCAE criteria [ Designated as safety issue: Yes ]
  • Clinical benefit response [ Designated as safety issue: No ]
Same as current
Not Provided
Not Provided
 
Cetuximab and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot Be Removed by Surgery
Locally Advanced Pancreatic Cancer: Phase II Study of Cetuximab and 3-D Conformal Image Guided Radiotherapy (PACER)

RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Radiation therapy uses high energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Giving cetuximab together with 3-dimensional conformal radiation therapy may kill more tumor cells.

PURPOSE: This phase II trial is studying how well giving cetuximab together with radiation therapy works in treating patients with locally advanced pancreatic cancer that cannot be removed by surgery.

OBJECTIVES:

Primary

  • To evaluate the progression free survival rate in patients treated with cetuximab and radiotherapy.

Secondary

  • To determine the response rate, toxicity of the combined regimen, and clinical benefit response in patients treated with cetuximab and radiotherapy.

OUTLINE: Patients receive cetuximab IV over 1-2 hours once weekly for 6-7 weeks. Patients also undergo concurrent 3-dimensional image-guided conformal radiotherapy in 28-30 fractions over approximately 5.5-6 weeks (2-4 hours after administration of cetuximab).

After completion of study treatment, patients are followed every 3 months for 1 year and then every 6 months for up to 3 years.

Interventional
Phase 2
Masking: Open Label
Primary Purpose: Treatment
Pancreatic Cancer
  • Biological: cetuximab
  • Radiation: 3-dimensional conformal radiation therapy
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
44
October 2010
September 2010   (final data collection date for primary outcome measure)

DISEASE CHARACTERISTICS:

  • Histopathologically or cytologically confirmed diagnosis of inoperable, non-metastatic, locally advanced pancreatic adenocarcinoma
  • No neuroendocrine tumors or lymphoma of the pancreas
  • No extensive disease unable to be covered in a radically treatable radiotherapy volume

PATIENT CHARACTERISTICS:

  • Karnofsky performance status 60-100%
  • Life expectancy > 3 months
  • Hemoglobin ≥ 10g/dL
  • WBC ≥ 3,000/mm³
  • ANC ≥ 1,500/mm³
  • Platelet count ≥ 100,000/mm³ (prior transfusions for patients with low hemoglobin allowed)
  • Total bilirubin ≤ 1.5 times upper limit of normal (ULN)
  • ALT and AST ≤ 1.5 times ULN
  • Alkaline phosphatase ≤ 1.5 times ULN
  • Serum urea ≤ 1.5 times ULN
  • Creatinine ≤ 1.5 times ULN
  • Adequate biliary drainage with no evidence of active uncontrolled infection (patients on prophylactic antibiotics are eligible)
  • Not pregnant or nursing
  • Negative pregnancy test
  • Women and men of child-bearing potential should be using an adequate contraception method, which must be continued for 3 months after completion of therapy
  • No unresolved biliary tract obstruction
  • No history of prior malignancy that may interfere with the response evaluation except for any of the following:

    • Cervical carcinoma in-situ treated by cone-biopsy/resection
    • Nonmetastatic basal and/or squamous cell carcinomas of the skin
    • Any early stage (stage I) malignancy adequately resected for cure greater than 5 years previously
  • No relative contraindication to radiotherapy
  • No evidence of severe uncontrolled systemic diseases or laboratory finding that in the view of investigator makes it undesirable for the patient to participate in the trial
  • No disorder likely to impact compliance with the protocol

PRIOR CONCURRENT THERAPY:

  • Must be completely recovered from previous surgery
  • The following prior interventions are allowed:

    • Non-curative operation (i.e., R2 resection with macroscopic residual disease evident on CT scan or palliative bypass procedure)
    • Stent insertion in the common bile duct
  • No previous radiotherapy within current treatment field
  • No previous administration of EGF monoclonal antibodies, EGFR signal transduction inhibitors or EGFR-targeted therapy
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT00599833
CHNT-PACER, CDR0000582420, EUDRACT-2006-001742-13, EU-207103, CTA-21266/0210/001-0001
Not Provided
Not Provided
Christie Hospital NHS Foundation Trust
Not Provided
Study Chair: Pat Price, MD Christie Hospital NHS Foundation Trust
National Cancer Institute (NCI)
August 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP