Language Function in Patients With Brain Tumors

This study has been completed.
Sponsor:
Information provided by:
Memorial Sloan-Kettering Cancer Center
ClinicalTrials.gov Identifier:
NCT00599703
First received: January 11, 2008
Last updated: July 7, 2009
Last verified: July 2009

January 11, 2008
July 7, 2009
May 2005
March 2009   (final data collection date for primary outcome measure)
To identify language organization prior to surgery in patients in whom a tumor invades or is directly adjacent to the expected location of one of the language centers. [ Time Frame: conclusion of study ] [ Designated as safety issue: No ]
Same as current
Complete list of historical versions of study NCT00599703 on ClinicalTrials.gov Archive Site
To assess language reorganization over time. [ Time Frame: conclusion of study ] [ Designated as safety issue: No ]
Same as current
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Language Function in Patients With Brain Tumors
Reorganization of Language Function in Patients With Brain Tumors

The purpose of this study is to use an imaging method called functional magnetic resonance imaging (fMRI) in patients who have a tumor near an area of the brain that is believed to control language. The fMRI is a new kind of imaging that uses a strong magnetic field to look at functioning brain tissue. This kind of imaging will be used to study the effect of the brain tumor on your speech.

Not Provided
Observational
Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample

MSKCC clinics

  • Brain Cancer
  • CNS Cancer
Other: fMRI Scan, pre- and post language evaluation
All subjects will undergo functional MR imaging, pre- and post-surgical language evaluation, and electrocortical stimulation mapping. The brain tumor patients will undergo these procedures twice.
1
neurosurgical patients
Intervention: Other: fMRI Scan, pre- and post language evaluation
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
7
March 2009
March 2009   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Patient in whom a tumor invades or is directly adjacent to the expected location of one of the language centers.
  • At least 18 years of age
  • English as first language

Exclusion Criteria:

  • Patients with high grade tumors
  • History of significant psychiatric condition (e.g. schizophrenia, obsessive-compulsive disorder, significant dementia),
  • History of the following neurological conditions: CVA, demyelinating conditions, cerebral palsy, Alzheimer's disease.
  • History of significant claustrophobic reactions.
  • Pregnancy
  • Standard contraindications to MR examinations (e.g. implanted stimulator)
  • Patients, who were treated prior to our first scan, will not be eligible to participate in this study
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00599703
05-043
Not Provided
Andrei Holodny, M.D., Memorial Sloan-Kettering Cancer Center
Memorial Sloan-Kettering Cancer Center
Not Provided
Principal Investigator: Andrei Holodny, MD Memorial Sloan-Kettering Cancer Center
Memorial Sloan-Kettering Cancer Center
July 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP