Researchers preliminary studies with epoxy skin phantoms have shown that liquid CO2 spray is effective to protect the epidermis during dermatologic laser therapy. This study is to characterize the clinical cutaneous effects of varying spurt durations and spurt delivery patterns of CSC in Fitzpatrick skin types I-VI.

However, the lower temperature induced by CO2 spray may tend to cause stronger cutaneous effects. It is researchers hypothesis that spurt durations of 80 ms or less will result in a very low incidence (less than 2%) of clinical skin effects (redness, blistering, local skin allergic reaction or skin discoloration) in any skin type.

Cryogen spray cooling (CSC) is a method to cool and thus, protect the epidermis which is used with dermatologic laser therapy to decrease treatment pain, allow safe treatment of darker skin types, and safe use of high laser fluences.

CSC with Tetrafluoroethane has been incorporated into many Food and Drug Administration approved, commercially available laser devices currently used for treatment of vascular lesions, hair removal and non-ablative skin rejuvenation. A millisecond cryogen spurt is applied to the skin surface immediately before laser exposure.

Inclusion Criteria:

• Adult 18 years and older

Exclusion Criteria:

• Age <18
• History of cold sensitivity
• Inflammatory rash on the test site

• Beckman Laser Institute University of California Irvine
• Candela Corporation