Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome

This study is currently recruiting participants.

Verified September 2011 by Washington University School of Medicine

Sponsor:

Information provided by (Responsible Party):

Washington University School of Medicine

ClinicalTrials.gov Identifier:

NCT00565903

First received: November 29, 2007

Last updated: September 22, 2011

Last verified: September 2011

History of Changes

Tracking Information

First Received Date ^ICMJE

November 29, 2007

Last Updated Date

September 22, 2011

Start Date ^ICMJE

March 2005

Primary Completion Date

Not Provided

Current Primary Outcome Measures ^ICMJE

Identify the genetic factors which contribute to the development or progression of pleuropulmonary blastoma [ Time Frame: 10 years ] [ Designated as safety issue: No ]

Original Primary Outcome Measures ^ICMJE

Same as current

Change History

Complete list of historical versions of study NCT00565903 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Define the clinical features of the pleuropulmonary blastoma (PPB) familial cancer syndrome. [ Time Frame: 10 years ] [ Designated as safety issue: No ]

Original Secondary Outcome Measures ^ICMJE

Same as current

Current Other Outcome Measures ^ICMJE

Not Provided

Original Other Outcome Measures ^ICMJE

Not Provided

Descriptive Information

Brief Title ^ICMJE

Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome

Official Title ^ICMJE

Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome

Brief Summary

Pleuropulmonary Blastoma (PPB) is a rare lung tumor which develops in childhood. The underlying genetic factors which contribute to the development and progression of PPB is not defined. We are working to identify the genetic factors which may contribute to the development of this rare tumor.

Detailed Description

Not Provided

Study Type ^ICMJE

Observational

Study Design ^ICMJE

Observational Model: Family-Based
Time Perspective: Prospective

Target Follow-Up Duration

Not Provided

Biospecimen

Retention: Samples With DNA

Description:

We are collecting blood samples or saliva samples. When available, we also collect tumor samples from prior surgical procedures.

Sampling Method

Non-Probability Sample

Study Population

Families who have a child or adult with pleuropulmonary blastoma or cystic nephroma are invited to participate.

Condition ^ICMJE

Pleuropulmonary Blastoma
Cystic Nephroma

Intervention ^ICMJE

Not Provided

Study Group/Cohort (s)

Not Provided

Publications *

Not Provided

* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Recruiting

Estimated Enrollment ^ICMJE

2000

Estimated Completion Date

March 2015

Primary Completion Date

Not Provided

Eligibility Criteria ^ICMJE

Inclusion Criteria:

child or adult diagnosed with pleuropulmonary blastoma or cystic nephroma.

Exclusion Criteria:

child or adult who does not have a confirmed diagnosis of pleuropulmonary blastoma or cystic nephroma.

Gender

Both

Ages

up to 95 Years

Accepts Healthy Volunteers

Yes

Contacts ^ICMJE

Contact: Paul Goodfellow, Ph.D.	314-362-2032	goodfellowp@wudosis.wustl.edu
Contact: Jennifer L. Ivanovich, MS, MBA	314-454-5076	jen@ccadmin.wustl.edu

Location Countries ^ICMJE

United States

Administrative Information

NCT Number ^ICMJE

NCT00565903

Other Study ID Numbers ^ICMJE

05-0192 / 201012830

Has Data Monitoring Committee

Responsible Party

Washington University School of Medicine

Study Sponsor ^ICMJE

Washington University School of Medicine

Collaborators ^ICMJE

Not Provided

Investigators ^ICMJE

Principal Investigator:	Paul Goodfellow, PhD	Washington University School of Medicine
Study Director:	Jennifer Ivanovich, MS, MBA	Washington University School of Medicine
Study Chair:	Ashley Hill, MD	Children's Research Institute
Study Chair:	Jack Priest, MD	Children's Hospital and Clinics of Minnesota

Information Provided By

Washington University School of Medicine

Verification Date

September 2011

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP

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