Mechanism and Efficacy of Rehabilitation Approaches

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2010 by Chang Gung Memorial Hospital.
Recruitment status was  Recruiting
Sponsor:
Collaborators:
National Science Council, Taiwan
National Health Research Institutes, Taiwan
Information provided by:
Chang Gung Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00564005
First received: November 25, 2007
Last updated: May 25, 2010
Last verified: May 2010

November 25, 2007
May 25, 2010
January 2008
December 2010   (final data collection date for primary outcome measure)
Cortical reorganization and kinematic analysis [ Time Frame: 2008-2010 ] [ Designated as safety issue: Yes ]
Cortical reorganization and kinematic analysis [ Time Frame: 2008-2010 ]
Complete list of historical versions of study NCT00564005 on ClinicalTrials.gov Archive Site
clinical measures at the impairment, activity, participation levels [ Time Frame: 2008-2010 ] [ Designated as safety issue: Yes ]
clinical measures at the impairment, activity, participation levels [ Time Frame: 2008-2010 ]
Not Provided
Not Provided
 
Mechanism and Efficacy of Rehabilitation Approaches
Mechanisms and Long-term Effects of Separate vs. Coupled Rehabilitation Approaches After Stroke

Identify the possible mechanisms and the relative effectiveness of existing rehabilitation approaches that target upper extremity deficits of stroke patients on the ground that these approaches are based on neuroplasticity principles and sound motor control theories.

Comparisons of constraint-induced therapy vs. bilateral arm training vs. combined therapy were made. Stroke patients will receive one of these three approaches and be evaluated pre- and post-treatment. the treatment will last 3 weeks and 5 days per week. The evaluation will include clinical measures of motor function, ADL, and quality of life, kinematic performance, and activation patterns of cortex.

Interventional
Not Provided
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Cerebrovascular Accidents
  • Other: Constraint-induced therapy (CIT)
    restraint of the unaffected arm and practice of the affected arm
  • Other: Bilateral arm training (BAT)
    bilateral symmetric, repetitive arm training
  • Other: Combined therapy (CT)
    combined different treatment approaches
  • Experimental: 1
    constraint-induced therapy
    Intervention: Other: Constraint-induced therapy (CIT)
  • Experimental: 2
    bilateral arm training
    Intervention: Other: Bilateral arm training (BAT)
  • Experimental: 3
    combined therapy
    Intervention: Other: Combined therapy (CT)
Wu CY, Chen YA, Lin KC, Chao CP, Chen YT. Constraint-induced therapy with trunk restraint for improving functional outcomes and trunk-arm control after stroke: a randomized controlled trial. Phys Ther. 2012 Apr;92(4):483-92. doi: 10.2522/ptj.20110213. Epub 2012 Jan 6.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
90
December 2010
December 2010   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • a first-ever clinical cerebrovascular accident patients
  • at least 6 months post-stroke onset
  • premorbid right-hand dominance
  • demonstration of Brunnstrom stage III of the affected upper extremity
  • no excessive spasticity in the joints of the affected upper extremity

Exclusion Criteria:

  • a score of less than 24 on the Mini Mental State Exam
  • poor physical conditions that would interfere with participation
  • excessive pain in any joint that might limit participation
Both
40 Years to 75 Years
No
Contact: Ching-yi Wu, ScD 886-3-2118800 ext 5761 cywu@mail.cgu.edu.tw
Taiwan
 
NCT00564005
NHRI-EX97-9742PI, 96-0252B
No
Ching-yi Wu, Chang Gung University
Chang Gung Memorial Hospital
  • National Science Council, Taiwan
  • National Health Research Institutes, Taiwan
Principal Investigator: Ching-yi Wu, ScD Department of Occupational Therapy, Chang Gung Univ.
Chang Gung Memorial Hospital
May 2010

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP