Simvastatin Reduces Adiponectin Levels and Insulin Sensitivity

This study has been completed.
Sponsor:
Information provided by:
Gachon University Gil Medical Center
ClinicalTrials.gov Identifier:
NCT00546182
First received: October 17, 2007
Last updated: NA
Last verified: October 2007
History: No changes posted

October 17, 2007
October 17, 2007
January 2004
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simvastatin may reduce adiponectin levels and insulin sensitivity in overweight hypercholesterolemic patients
Same as current
No Changes Posted
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Simvastatin Reduces Adiponectin Levels and Insulin Sensitivity
Phase 4 Study of Simvastatin That Affects Insulin Sensitivity

We hypothesized simvastatin may reduce adiponectin levels and insulin sensitivity in overweight hypercholesterolemic patients.

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Observational
Observational Model: Case Control
Time Perspective: Prospective
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overweight hypercholesterolemic patients

Hypercholesterolemia
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Yada T, Nakata M, Shiraishi T, Kakei M. Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells. Br J Pharmacol. 1999 Mar;126(5):1205-13.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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Inclusion Criteria:

  • Low-density lipoprotein cholesterol levels more than 100 and body mass index more than 23.0

Exclusion Criteria:

  • Patients with overt liver disease
  • Chronic renal failure
  • Hypothyroidism, myopathy
  • Uncontrolled diabetes
  • Severe hypertension, stroke
  • Acute coronary events
  • Coronary revascularization within the preceding 3 months, or
  • Alcohol abuse.
Both
25 Years to 75 Years
No
Contact information is only displayed when the study is recruiting subjects
Korea, Republic of
 
NCT00546182
GMC-200405
Yes
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Gachon University Gil Medical Center
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Principal Investigator: Kwang K Koh, MD,PhD Gachon University Gil Medical Center
Gachon University Gil Medical Center
October 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP