A Long-Term Examination of Asthma From Childhood Through Adolescence

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Professor S Hasan Arshad, Isle of Wight NHS Trust
ClinicalTrials.gov Identifier:
NCT00541255
First received: October 9, 2007
Last updated: November 9, 2013
Last verified: November 2013

October 9, 2007
November 9, 2013
September 2007
May 2012   (final data collection date for primary outcome measure)
Identifying factors that may increase a person's chance of having recurrent asthma as an adult [ Time Frame: Measured throughout the participant's lifetime ] [ Designated as safety issue: No ]
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Complete list of historical versions of study NCT00541255 on ClinicalTrials.gov Archive Site
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A Long-Term Examination of Asthma From Childhood Through Adolescence
Epidemiology of Asthma and Allergic Disease: Risk and Prognosis in a Cohort From Birth to Adolescence

Asthma is a common disease that is often diagnosed in childhood. In some teenagers, asthma symptoms disappear and treatment can be stopped; however, for some of these people, asthma symptoms return in adulthood. This study will examine data collected over the lifetime of 18-year olds to identify factors that may increase a person's chance of having recurrent asthma as an adult.

Asthma is a serious, long-term illness that affects around 15% of children in the United States. During adolescence, up to 50% of teenagers stop experiencing symptoms and are able to discontinue treatment. However, asthma symptoms often reoccur in adulthood for many of these people. It is not known exactly what causes this recurrence, but potential risk factors may include obesity, elevated serum leptin levels, early onset of puberty, exposure to pollutants, parental smoking habits, and lack of breastfeeding. Additionally, it is not known why childhood asthma is initially more prevalent in boys, but during adolescence it becomes more prevalent in girls. Beginning in 1989, a group of children born on the Isle of Wight in the United Kingdom has been followed by study researchers to provide long-term information on asthma. These children have been periodically evaluated over the years and are now 18 years old. The purpose of this study is to analyze participants' data collected over a span of 18 years to identify factors that may increase a person's risk of experiencing persistent or recurrent asthma in adulthood.

At previous study visits that occurred when participants were 1, 2, 4, and 10 years old, information on the following was collected: asthma and other allergic diseases, family history of asthma, and early life risk factors, including breastfeeding and tobacco smoke exposure. A blood sample was collected at participants' 10-year study visit. For this current study, all 18-year-old participants will return for a study visit. Participants will complete questionnaires on asthma and allergy symptoms and environmental exposures, including tobacco smoke and pollution. Blood collection, an allergy skin prick test, lung function testing, and a bronchial challenge test to assess airway function will occur. Select participants will also have a sputum sample collected.

Observational
Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:

Whole blood, serum, saliva, urine

Non-Probability Sample

The study population consists of around 1500 unselected subjects (now age 18) who were recruited at birth. This is a homogenous population with 99% being Caucasians.

  • Asthma
  • Dermatitis, Atopic
  • Rhinitis
  • Urticaria
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Active, not recruiting
1200
December 2014
May 2012   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Born on the Isle of Wight in the United Kingdom between January 1, 1989 and February 28, 1990

Exclusion criteria:

  • Refused consent
Both
17 Years to 19 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United Kingdom
 
NCT00541255
1408, R01HL082925, 1 R01 HL082925-01A2
No
Professor S Hasan Arshad, Isle of Wight NHS Trust
Isle of Wight NHS Trust
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Syed Arshad, MD University of Southampton, United Kingdom
Isle of Wight NHS Trust
November 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP