Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas

This study has been completed.

Sponsor:

Information provided by (Responsible Party):

Martin Grossherr, University of Luebeck

ClinicalTrials.gov Identifier:

NCT00532402

First received: September 18, 2007

Last updated: October 29, 2012

Last verified: October 2012

History of Changes

Tracking Information

First Received Date ^ICMJE

September 18, 2007

Last Updated Date

October 29, 2012

Start Date ^ICMJE

September 2007

Primary Completion Date

Not Provided

Current Primary Outcome Measures ^ICMJE

Not Provided

Original Primary Outcome Measures ^ICMJE

Not Provided

Change History

Complete list of historical versions of study NCT00532402 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Not Provided

Original Secondary Outcome Measures ^ICMJE

Not Provided

Current Other Outcome Measures ^ICMJE

Not Provided

Original Other Outcome Measures ^ICMJE

Not Provided

Descriptive Information

Brief Title ^ICMJE

Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas

Official Title ^ICMJE

Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas - Compared With Propofol Concentration in Plasma (Before and) After Lung Passage and Neurophysiological Parameters

Brief Summary

This study should compare the propofol concentration in breathing gas and in plasma (before and) after lung passage. Propofol concentrations in breathing gas are continuously measured by a sensor. For comparison a discontinuous method is used. Neurophysiologic parameters for determination of depth of anesthesia are compared to the continuous measured propofol concentration in breathing gas.

Study hypothesis: continuous measured propofol concentration in breathing gas correlates to propofol concentration in plasma and depth of anaesthesia.

Detailed Description

Not Provided

Study Type ^ICMJE

Observational

Study Design ^ICMJE

Observational Model: Cohort
Time Perspective: Prospective

Target Follow-Up Duration

Not Provided

Biospecimen

Not Provided

Sampling Method

Probability Sample

Study Population

Patients having general anesthesia for cardiac and non-cardiac operation

Condition ^ICMJE

General Anesthesia

Intervention ^ICMJE

Not Provided

Study Group/Cohort (s)

Not Provided

Publications *

Grossherr M, Hengstenberg A, Meier T, Dibbelt L, Gerlach K, Gehring H. Discontinuous monitoring of propofol concentrations in expired alveolar gas and in arterial and venous plasma during artificial ventilation. Anesthesiology. 2006 Apr;104(4):786-90.

* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Completed

Estimated Enrollment ^ICMJE

Completion Date

December 2010

Primary Completion Date

Not Provided

Eligibility Criteria ^ICMJE

Inclusion Criteria:

Patient destined for general anesthesia

Exclusion Criteria:

Heart insufficiency NYHA IV
Allergy to propofol

Gender

Both

Ages

18 Years to 90 Years

Accepts Healthy Volunteers

Contacts ^ICMJE

Contact information is only displayed when the study is recruiting subjects

Location Countries ^ICMJE

Germany

Administrative Information

NCT Number ^ICMJE

NCT00532402

Other Study ID Numbers ^ICMJE

P-A-S-1

Has Data Monitoring Committee

Responsible Party

Martin Grossherr, University of Luebeck

Study Sponsor ^ICMJE

University of Luebeck

Collaborators ^ICMJE

Not Provided

Investigators ^ICMJE

Study Director:

Hartmut Gehring, MD, PhD

Dept of Anesthesiology, UK-SH, Campus Luebeck

Information Provided By

University of Luebeck

Verification Date

October 2012

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP

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