Now Available for Public Comment: Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

Effect of Donepezil on the Reorganization of Cognitive Neural Network in Patients With Post-Stroke Cognitive Impairment

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2007 by Samsung Medical Center.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT00530478
First received: September 13, 2007
Last updated: NA
Last verified: July 2007
History: No changes posted

September 13, 2007
September 13, 2007
Not Provided
Not Provided
Not Provided
Not Provided
No Changes Posted
Not Provided
Not Provided
Not Provided
Not Provided
 
Effect of Donepezil on the Reorganization of Cognitive Neural Network in Patients With Post-Stroke Cognitive Impairment
Not Provided

The purpose of this study is to demonstrate the efficacy and safety of donepezil on the recovery of cognitive function in patients with stroke and to delineate the neurophysiologic mechanisms of the therapeutic effect of donepezil on the recovery of cognitive network using functional neuroimaging technique.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Stroke
Drug: Donepezil
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
Not Provided
Not Provided
Not Provided

Inclusion Criteria:

  • Ischemic stroke in the territory of right or left middle cerebral artery
  • Post-onset duration of the recent-onset stroke is over 3 months
  • Cognitive deficit ranged from 10 to 26 by minimal mental status examination (MMSE) score
  • Disturbance in activities of daily living (ADL) ranged 0.5 ~ 2.0 by clinical dementia rating (CDR) scale

Exclusion Criteria:

  • Severe internal carotid artery stenosis on the lesion side
  • Cardiac pacemaker or intracranial metal insertion
  • Post-stroke seizure disorder or any evidence of epileptic spikes on electroencephalography (EEG)
Both
16 Years to 80 Years
Not Provided
Contact: Yun-Hee Kim, MD, PHD 82-2-3410-2818 yunkim@smc.samsung.co.kr
Korea, Republic of
 
NCT00530478
2006-04-023
Yes
Not Provided
Samsung Medical Center
Not Provided
Principal Investigator: Suk Hoon Ohn, MD, MS Samsung Medical Center
Principal Investigator: Yun Hee Park, MD Samsung Medical Center
Samsung Medical Center
July 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP