Neuroimaging Studies of Depression in Parkinson's Disease

This study has been completed.
Sponsor:
Collaborators:
Information provided by (Responsible Party):
Lee Blonder, University of Kentucky
ClinicalTrials.gov Identifier:
NCT00518258
First received: August 16, 2007
Last updated: May 16, 2013
Last verified: April 2013

August 16, 2007
May 16, 2013
July 2006
December 2011   (final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00518258 on ClinicalTrials.gov Archive Site
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Neuroimaging Studies of Depression in Parkinson's Disease
Neuroimaging Studies of Depression in Parkinson's Disease

The purpose of this study is to investigate similarities and differences in the neural pathways of depressed Parkinson's patients, non-depressed Parkinson's patients, and healthy controls using magnetic resonance imaging (MRI) of the brain and neuropsychological assessment.

Depression is a common and potentially serious complication of Parkinson's disease (PD). Studies show that approximately 40 percent of PD patients are depressed. There is evidence that these patients have deficits in neuropsychological function relative to non-depressed PD patients. Despite the widespread toll on emotional health posed by PD, few studies have undertaken a comprehensive examination of the neural underpinnings of Parkinsonian depression. In this project, we will compare depressed versus non-depressed Parkinson patients to a sample of demographically-matched healthy controls using neuropsychological assessment and magnetic resonance imaging (MRI). To investigate possible effects of anti-Parkinsonian medication on mood, cognitive function, and neural response, PD patients will be tested both off and on Parkinsonian medications.

Observational
Observational Model: Case Control
Time Perspective: Prospective
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Non-Probability Sample

Neurology clinics, community sample

Parkinson's Disease
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  • 1
    Patient Group
  • 2
    Control Group
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
120
December 2011
December 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • right-handed
  • willing/able to undergo magnetic resonance imaging (MRI)

Exclusion Criteria:

  • history of neurological condition other than Parkinson's disease
  • history of psychiatric condition other than depression
  • history of substance abuse/dependence
Both
40 Years to 85 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00518258
R01-MH78228-2
No
Lee Blonder, University of Kentucky
Lee Blonder
  • National Institute of Mental Health (NIMH)
  • National Institute of Neurological Disorders and Stroke (NINDS)
Principal Investigator: Lee X. Blonder, PhD University of Kentucky
University of Kentucky
April 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP