Role of Volatile Anesthetics for Hepatic Protection - Tabular View

Tracking Information

First Received Date ^ICMJE

August 14, 2007

Last Updated Date

October 22, 2009

Start Date ^ICMJE

March 2006

Primary Completion Date

December 2007 (final data collection date for primary outcome measure)

Current Primary Outcome Measures ^ICMJE

Blood levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT)

Original Primary Outcome Measures ^ICMJE

Same as current

Change History

Complete list of historical versions of study NCT00516711 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Original Secondary Outcome Measures ^ICMJE

Descriptive Information

Brief Title ^ICMJE

Role of Volatile Anesthetics for Hepatic Protection

Official Title ^ICMJE

Role of Volatile Anesthetics for Hepatic Protection in Ischemia-reperfusion

Brief Summary

This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of liver enzymes, reduced production of inflammatory mediators).

Detailed Description

Organ protection; preconditioning; volatile anesthetics; ischemia reperfusion

Study Phase

Study Type ^ICMJE

Interventional

Study Design ^ICMJE

Prevention, Randomized, Open Label, Placebo Control, Parallel Assignment, Pharmacodynamics Study

Condition ^ICMJE

Reperfusion Injury

Intervention ^ICMJE

Drug: Sevoflurane

Study Arms / Comparison Groups

Publications *

Beck-Schimmer B, Breitenstein S, Urech S, De Conno E, Wittlinger M, Puhan M, Jochum W, Spahn DR, Graf R, Clavien PA. A randomized controlled trial on pharmacological preconditioning in liver surgery using a volatile anesthetic. Ann Surg. 2008 Dec;248(6):909-18.

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Completed

Enrollment ^ICMJE

Completion Date

December 2007

Primary Completion Date

December 2007 (final data collection date for primary outcome measure)

Eligibility Criteria ^ICMJE

Inclusion Criteria:

Older than 18 years of age
Patients undergoing liver resection (benign or malignant tumors)

Exclusion Criteria:

Laparoscopic liver resection coagulopathy (platelets < 50,000/ml, Quick < 50%)
Liver cirrhosis

Gender

Both

Ages

18 Years to 75 Years

Accepts Healthy Volunteers

Yes

Contacts ^ICMJE

Contact information is only displayed when the study is recruiting subjects

Location Countries ^ICMJE

Switzerland

Administrative Information

NCT ID ^ICMJE

NCT00516711

Responsible Party

Study ID Numbers ^ICMJE

StV 5-2006

Study Sponsor ^ICMJE

University of Zurich

Collaborators ^ICMJE

Investigators ^ICMJE

Study Director:

01 Studienregister MasterAdmins

UniversitaetsSpital Zuerich

Information Provided By

University of Zurich

Verification Date

August 2007

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP