Blood Collection From Individuals With Lung Disease for Genetic Studies (Qatar) (Q-BC)

This study has been completed.
Sponsor:
Collaborators:
Weill Cornell Medical College in Qatar
Hamad Medical Corporation
Information provided by (Responsible Party):
Weill Medical College of Cornell University
ClinicalTrials.gov Identifier:
NCT00504361
First received: July 19, 2007
Last updated: December 19, 2013
Last verified: December 2013

July 19, 2007
December 19, 2013
May 2006
Not Provided
Not Provided
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Complete list of historical versions of study NCT00504361 on ClinicalTrials.gov Archive Site
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Blood Collection From Individuals With Lung Disease for Genetic Studies (Qatar)
Collection of Blood for Gene Expression Study in Individuals With Chronic Lung Diseases (Qatar)

This is a research study where researchers are collecting blood to evaluate the genetic characteristics of individuals with chronic lung diseases, including asthma, COPD (chronic obstructive pulmonary disease), interstitial lung disease, cystic fibrosis, and lung cancer. The investigators hope to be able to identify an association between a genetic make-up in the blood samples and the risks of developing a particular lung disease, or severity of a lung disease. The findings of this study might be important to develop future preventative methods and potential treatments for the management of lung disease.

This protocol is designed to collect a small amount of blood for extraction of DNA (genetic material) for the study of the genetic basis of lung disease. The study population will include individuals with known lung diseases and controls without lung disease. Individuals in the study population will be individuals at the Hamad Medical Corporation, Qatar (HMC), as well as other individuals recruited for this study. In this protocol, researchers will survey medical records of patients with chronic lung disease, in order to study the clinical characteristics of these individuals, and the researchers will collect blood to evaluate the genetic characteristics of individuals with chronic lung diseases including asthma, and COPD (chronic obstructive pulmonary disease), pulmonary fibrosis, and lung cancer. The researchers will also collect blood samples of individuals without lung disease to serve as control.

This protocol, to be carried out at Weill Cornell Medical College - Qatar and Hamad Medical Corporation, Qatar, parallels a similar approved protocol IRB #0508008095, entitled, "Collection of Blood for Gene Expression/Genomic Studies in Individuals with Chronic Lung Diseases", ongoing at Weill Cornell Medical College - New York.

Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

This protocol is designed to collect a small amount of blood for extraction of DNA (genetic material) for the study of the genetic basis of lung disease. Genomic DNA will be extracted, and genome wide SNP analysis and promoter sequences for genes will be obtained. The goal is to find single nucleotide polymorphims (SNP), small changes in single genes that affect disease risk, to see if they correlate with lung disease.

Non-Probability Sample

Individuals visiting the Medicine Department at the Hamad Medical Corporation, Qatar for standard clinical care will be recruited.

Controls will be obtained from volunteers without a history of lung disease. Family members of patients may be asked to participate in the study.

  • Asthma
  • COPD
  • Interstitial Lung Disease
  • Cystic Fibrosis
  • Lung Cancer
Not Provided
  • 1: Lung Disease
    Individuals with at least one of the following: (1) symptoms consistent with pulmonary disease; (2) chest X-ray consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; (6) patients with diseases of organs with known association with lung disease; and (7) individuals suspected of history of lung diseased based on history and/or physical examination
  • 2: Normal Control
    Individuals without a history of lung disease.
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
600
May 2012
Not Provided

Lung Disease group. Individuals with lung disease who fit the following criteria will be enrolled.

Inclusion criteria

  • Must provide informed consent
  • Males and females, age 18 years and older
  • Evidence of lung disease proven by at least one of the following: (1) symptoms consistent with pulmonary disease; (2) chest X-rays and/or chest CT consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; and (6) diseases of organs with known association with lung disease; and (7) individuals suspected of history of lung diseased based on history and/or physical examination

Exclusion criteria

  • Individual refuses consent.

Normal control group. For the purpose of this protocol, "normal" will include individuals without history of chronic lung disease, including asthma, and without recurrent or recent (within 3 months) acute pulmonary disease, and will be determined by the following criteria:

Inclusion Criteria:

  • Must provide informed consent.
  • Males or females ages 18 years and older.
  • Non-smokers, ex-smokers and smokers.

Exclusion Criteria:

  • Individual refuses consent.
  • Individuals with history of chronic lung disease, including asthma or with recurrent or recent (within three months) acute pulmonary disease will not be accepted into the study.
Both
18 Years to 90 Years
Yes
Contact information is only displayed when the study is recruiting subjects
Qatar
 
NCT00504361
0605008516, HMC RC#373/2006
No
Weill Medical College of Cornell University
Weill Medical College of Cornell University
  • Weill Cornell Medical College in Qatar
  • Hamad Medical Corporation
Principal Investigator: Ronald G Crystal, MD Weill Cornell Medical College, NY and Qatar
Weill Medical College of Cornell University
December 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP